Purchase this article with an account.
H. Ishikawa, J. S. Kim, G. Wollstein, R. A. Bilonick, L. Kagemann, P. Brennen, J. S. Schuman; Standardizing Retinal Nerve Fiber Layer (RNFL) Thickness Measurements Across Time Domain and Spectral Domain Optical Coherence Tomography (TD- and SD-OCT) Devices While Accounting for Scan Location. Invest. Ophthalmol. Vis. Sci. 2010;51(13):2974.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To standardize the RNFL thickness measurements among TD- and various SD-OCT devices by establishing calibration equations while accounting for variable TD-OCT scan location using a scan location matching (SLM) algorithm.
Eighteen eyes (11 healthy and 7 glaucoma) had nine circumpapillary TD-OCT (Stratus OCT; Carl Zeiss Meditec, Inc., Dublin, CA (CZMI)) scans (one centered and 8 intentionally off-centered). In addition, one 3D cube scan centered at the optic nerve head was obtained for each eye using 3 SD-OCT devices: Cirrus HD-OCT (CZMI), RTVue (Optovue, Fremont, CA), and Spectralis (Heidelberg Engineering, Heidelberg, Germany). Matched scan location for each TD-OCT scan (centered and off-centered) was detected on each of the 3 corresponding SD-OCT cube data using the SLM algorithm. RNFL thickness measurement calibration equations from TD- to SD-OCTs were computed separately.
Before calibration, the global mean RNFL thickness measurements of Cirrus, RTVue, and Spectralis were significantly higher than TD-OCT circle scan (16.6, 30.7, and 16.4% increase, respectively; p0.06) (Figure).
Calibration equations standardized RNFL thickness measurements so that they are directly comparable among TD- and various SD-OCT devices. This may allow us to longitudinally study populations across the OCT technology generations.
This PDF is available to Subscribers Only