Peculiarities of the Inflammatory-Reparative Reaction of Sclera After Diathermo-Coagulation in Experiment in vivo

Abstract

Purpose: : To study the influence of diathermo-coagulation on the character of the inflammatory-reparative reaction of sclera in experiment in vivo.

Methods: : A series of experiments was carried out with 50 Wistar mature rats. Animals of the 1^st group received conjunctivectomy and diathermo-coagulation of sclera, while animals of the 2^nd group received only conjunctivectomy. In the experiment, we conducted biomicroscopy and photographic recording of the anterior segment of an eye at the 1^st, 3^rd, 5^th, 7^th, 14^th, and 21^th day with the following histological investigation.

Results: : At the 21^st day, the conjunctival epithelium in animals of the 1^st group had the normal structure. The sclera was thickened. A heterogeneous edema of the ground substance was still observed. Fibroblasts predominated among cells. In animals of the 2^nd group, the conjunctival epithelium had the normal structure. The sclera was represented by a dense connective tissue.

Conclusions: : Diathermo-coagulation of sclera favors the development and maintenance of the inflammatory reaction, thus giving rise to prerequisites for excessive scarring.

Keywords: inflammation • regeneration • wound healing