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P. Doyle, P. R. Troyk, S. K. Kelly, D. B. Shire, J. L. Wyatt, Jr., J. F. Rizzo; Operation of a Wireless Retinal Implant Device With Reverse Telemetry. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3032. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. The specific purpose of this presentation is to describe the operation of a wireless retinal implant device with reverse telemetry and to present results obtained from its use.
A custom Application Specific Integrated Circuit (ASIC) was designed by Sigenics, Inc. and fabricated by X-Fab. This ASIC consists of a 16 channel neurostimulator coupled with wireless power and control circuitry and a wireless feedback channel. The ASIC was fitted into a hermetically sealed titanium case. A flexible polyimide electrode array was attached to feedthrough connectors on outside of the case. Operation of the neurostimulator was verified on the benchtop and via electrode waveform measurements transmitted wirelessly back to the controller.
The device was tested and calibrated with a simple series R-C load. In-vitro stimulation waveform data shows good correlation between the calibration waveforms measured with an oscilloscope, demonstrating that the reverse telemetry channel can be used to measure electrode impedance.
The custom ASIC provides a platform for making chronic impedance measurements of electrodes implanted subretinally. Further work is required to improve the accuracy and fidelity of the data reported.
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