April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Electrophysiological Evaluation of Rabbit Eyes Chronically Implanted With Electrode for Suprachoroidal Transretinal Stimulation
Author Affiliations & Notes
  • K. Nishida
    Osaka University, Suita, Japan
  • H. Sakaguchi
    Osaka University, Suita, Japan
  • T. Fujikado
    Osaka University, Suita, Japan
  • M. Kamei
    Osaka University, Suita, Japan
  • Footnotes
    Commercial Relationships  K. Nishida, None; H. Sakaguchi, None; T. Fujikado, None; M. Kamei, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3039. doi:
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      K. Nishida, H. Sakaguchi, T. Fujikado, M. Kamei; Electrophysiological Evaluation of Rabbit Eyes Chronically Implanted With Electrode for Suprachoroidal Transretinal Stimulation. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3039.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the safety and efficacy of a chronically implanted electrode for suprachoroidal transretinal stimulation (STS) in rabbit eyes.

Methods: : A platinum microelectrode was implanted into a scleral pocket of five rabbit eyes and assessed for 3 months. To evaluate its safety, fundus examinations, fluorescein angiographies, electroretinograms (ERGs), and visually evoked potentials (VEPs) were performed before and at 3 months after implantation. To evaluate its efficacy, electrically evoked potentials (EEPs) were measured immediately after the implantation and every month thereafter.

Results: : The electrode remained stable in the scleral pockets throughout the observation period in all rabbits. No intraocular infection, inflammation, or vitreoretinal proliferation was observed in any eye. The implicit times and amplitudes of the a- and b-waves of the ERGs nor VEPs did not change significantly throughout the post-implantation period. EEPs could be elicited from the STS electrodes at all testing times. The mean threshold currents to evoke EEPs did not change significantly during follow-up period and the current was 150.0 ± 68.5 µA at 3 month after implantation.

Conclusions: : Chronic implantation of a platinum electrode for STS appears to be safe and effective.

Keywords: electrophysiology: non-clinical • electroretinography: non-clinical • visual cortex 
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