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S. Lee, K.-I. Koo, J.-W. Ban, H.-Y. Jeong, H. Park, S.-J. Hong, S. H. Bae, J.-M. Seo, H. Chung, D. D. Cho; A Long-Term in vivo Biocompatibility Evaluation of PMMA Retinal Tack for Retinal Prosthesis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3044.
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© ARVO (1962-2015); The Authors (2016-present)
At the 2009 ARVO, we presented a poly-(methyl methacrylate) (PMMA) retinal tack with barb-shaped scale bars for epi-retinal implantation of retinal prosthesis. This paper presents long-term in vivo evaluation results of PMMA retinal tacks using New Zealand white rabbits.
The novel PMMA retinal tacks were fabricated using the microelectromechanical systems (MEMS) technology. In order to investigate the biocompatibility and durability, PMMA retinal tacks were implanted in an anesthetized rabbit eye. After 6 months of implantation, the retinal tacks were harvested and microscopically observed. The implanted sites were also histologically examined for any trace of inflammation.
To study progressive behavior, the microscopic histological examinations were performed after 4 weeks and 6 months from implantations in three rabbits. The histological results after 4 weeks and 6 months showed no inflammatory infiltrate in retina, choroid, or sclera. Furthermore, the mechanical stability of implanted device was investigated after 4 weeks and 6 months, respectively, using scanning electron microscope (SEM). The SEM images showed no chemical reaction trace nor mechanical fracture of the PMMA retinal tack.
The results show stable fixation in the rabbit eye, and indirect ophthalmoscopic examination reveals no retinal detachment. Based on these results, we believe that the PMMA retinal tacks have a strong potential for clinical applications.
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