April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
A Long-Term in vivo Biocompatibility Evaluation of PMMA Retinal Tack for Retinal Prosthesis
S. Lee; K.-I. Koo; J.-W. Ban; H.-Y. Jeong; H. Park; S.-J. Hong; S. H. Bae; J.-M. Seo; H. Chung; D. D. Cho
Author Affiliations & Notes
  • S. Lee
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-university Semiconductor Research Institute, Seoul, Republic of Korea
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
  • K.-I. Koo
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • J.-W. Ban
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • H.-Y. Jeong
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • H. Park
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • S.-J. Hong
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • S. H. Bae
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
  • J.-M. Seo
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
  • H. Chung
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
  • D. D. Cho
    Nano Artificial Vision Research Center, Seoul, Republic of Korea
    Electrical Engneering and Computer Science, Seoul National University College of Engineering, Automation and Systems Research Institute / Inter-University Semiconductor Research Institute, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  S. Lee, None; K.-I. Koo, None; J.-W. Ban, None; H.-Y. Jeong, None; H. Park, None; S.-J. Hong, None; S.H. Bae, None; J.-M. Seo, None; H. Chung, None; D.D. Cho, None.
  • Footnotes
    Support  Korea Health 21 R & D Project A050251 supported by MIHWAF
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3044. doi:
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      S. Lee, K.-I. Koo, J.-W. Ban, H.-Y. Jeong, H. Park, S.-J. Hong, S. H. Bae, J.-M. Seo, H. Chung, D. D. Cho; A Long-Term in vivo Biocompatibility Evaluation of PMMA Retinal Tack for Retinal Prosthesis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3044.

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Abstract

Purpose: : At the 2009 ARVO, we presented a poly-(methyl methacrylate) (PMMA) retinal tack with barb-shaped scale bars for epi-retinal implantation of retinal prosthesis. This paper presents long-term in vivo evaluation results of PMMA retinal tacks using New Zealand white rabbits.

Methods: : The novel PMMA retinal tacks were fabricated using the microelectromechanical systems (MEMS) technology. In order to investigate the biocompatibility and durability, PMMA retinal tacks were implanted in an anesthetized rabbit eye. After 6 months of implantation, the retinal tacks were harvested and microscopically observed. The implanted sites were also histologically examined for any trace of inflammation.

Results: : To study progressive behavior, the microscopic histological examinations were performed after 4 weeks and 6 months from implantations in three rabbits. The histological results after 4 weeks and 6 months showed no inflammatory infiltrate in retina, choroid, or sclera. Furthermore, the mechanical stability of implanted device was investigated after 4 weeks and 6 months, respectively, using scanning electron microscope (SEM). The SEM images showed no chemical reaction trace nor mechanical fracture of the PMMA retinal tack.

Conclusions: : The results show stable fixation in the rabbit eye, and indirect ophthalmoscopic examination reveals no retinal detachment. Based on these results, we believe that the PMMA retinal tacks have a strong potential for clinical applications.

Keywords: retina • retinal development • transplantation 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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