April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Surgical Implantation of 1.5 Generation Retinal Implant in Minipig Eyes
Author Affiliations & Notes
  • J. Chen
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
  • P. Doyle
    Center for Innovative Visual Rehabilitation, VA Medical Center, Boston, Massachusetts
  • C. Cai
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • J. Dumser
    Mass Eye and Ear Infirmary, Boston, Massachusetts
  • R. Akhmechet
    Mass Eye and Ear Infirmary, Boston, Massachusetts
    Cornell Nanofabrication Facility, Ithaca, New York
  • M. D. Gingerich
    Cornell Nanofabrication Facility, Ithaca, New York
    Ctr. for Innovative Visual Rehabilitation, VA Boston Healthcare System, Boston, Massachusetts
  • S. K. Kelly
    Boston Retinal Implant Project, Cambridge, Massachusetts
  • D. B. Shire
    Cornell Nanofabrication Facility, Ithaca, New York
    Ctr. for Innovative Visual Rehabilitation, VA Boston Healthcare System, Boston, Massachusetts
  • J. F. Rizzo
    Ophthalmology, Mass Eye & Ear Infirmary, Boston, Massachusetts
    Ctr. for Innovative Visual Rehabilitation, VA Boston Healthcare System, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  J. Chen, None; P. Doyle, None; C. Cai, None; J. Dumser, None; R. Akhmechet, None; M.D. Gingerich, None; S.K. Kelly, None; D.B. Shire, None; J.F. Rizzo, Bionic Eye, I; US, P.
  • Footnotes
    Support  NSF - # ISS_0515134; VA RR & D - C2726C; DoD - PR064776; TATRC - W81 XWH-07-01-0671
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3052. doi:
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      J. Chen, P. Doyle, C. Cai, J. Dumser, R. Akhmechet, M. D. Gingerich, S. K. Kelly, D. B. Shire, J. F. Rizzo; Surgical Implantation of 1.5 Generation Retinal Implant in Minipig Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3052.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. This presentation summarizes the surgical results of implantation of 1.5 generation retinal implant in minipig eyes.

 
Methods:
 

2 active and 10 inactive 1.5 generation retinal implants were implanted into 12 minipig eyes via an ab externo method to study in vivo electrical function and biocompatibility. Our active implants contain a circuitry module, secondary power and data receiving coils, and 15 µm-thick, 4mm wide polyimide-based flexible electrode arrays. 4/10(4 out of 10) inactive implants do not have arrays. To prevent excessive bleeding, "controlled" systemic hypotension was introduced during insertion. A local retinal detachment was created after vitrectomy. The coils were sutured around the cornea and the titanium cases were sutured onto sclera nasally. Electrode arrays were placed into subretinal space temporally with an ab externo method. Conjunctiva was closed over the implant.

 
Results:
 

7/8 electrode arrays were successfully implanted into subretinal space. 1 electrode array went into vitreous. Retinal incarceration happened in 1 surgery. No other surgical complications were observed. 3 pigs died of anesthesia complications after surgery. 7/11 eyes had exposure of the coils (5 eyes), the case (1 eye) and between the coil and the case (1 eye). 6/7 exposures happened nasally. Two active devices were functional for more than 2 months in vivo.

 
Conclusions:
 

Our 1.5 generation retinal implant can be safely implanted in Yucatan minipig eyes with our ab externo methods. More experiments will be done to improve the long term biocompatibility of our device.  

 
Keywords: vitreoretinal surgery • retinal detachment • conjunctiva 
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