April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Wet vs. Dry Age-Related Macular Degeneration in Patients With Central Field Loss : Different Effects on Maximum Reading Speed
Author Affiliations & Notes
  • A. Calabrese
    University Aix-Marseille II, CNRS - Institut de neurosciences cognitives de la Méditerranée INCM, Marseille, France
  • J.-B. Bernard
    School of Optometry, University of California, Berkeley, California
  • L. Hoffart
    Department of Ophthalmology, University Hospital of La Timone, Marseille, France
  • G. Faure
    Department of Ophthalmology, University Hospital of La Timone, Marseille, France
  • F. Barouch
    Department of Ophthalmology, University Hospital of La Timone, Marseille, France
  • J. Conrath
    Department of Ophthalmology, University Hospital of La Timone, Marseille, France
  • E. Castet
    University Aix-Marseille II, CNRS - Institut de Neurosciences Cognitives de la Méditerranée INCM, Marseille, France
  • Footnotes
    Commercial Relationships  A. Calabrese, None; J.-B. Bernard, None; L. Hoffart, None; G. Faure, None; F. Barouch, None; J. Conrath, None; E. Castet, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3063. doi:
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      A. Calabrese, J.-B. Bernard, L. Hoffart, G. Faure, F. Barouch, J. Conrath, E. Castet; Wet vs. Dry Age-Related Macular Degeneration in Patients With Central Field Loss : Different Effects on Maximum Reading Speed. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3063.

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Abstract

Purpose: : To compare reading performances between wet and dry age-related macular degeneration (AMD) patients with central field loss, while adjusting for relevant clinical factors.

Methods: : Linear mixed-effects (lme) analyses were performed on a dataset initially collected to assess the effect of interline spacing on Maximum Reading Speed (MRS). Monocular reading speed was measured in 90 eyes (64 dry and 26 wet) from 61 patients with AMD. French MNRead-like sentences were presented on a monitor with decreasing letter sizes at three different interline spacings (0.79X, 1X and 2X the standard). From these data, MRS was calculated for the 3 interline spacings. These 3 repeated measurements justified the use of lme analysis. Microperimetry (MP1) was used to determine the characteristics of scotomas (size, position, shape, …), the position of the Preferred Retinal Locus used during fixation (fPRL), and the distance between fPRL and fovea. Patients were included in the analysis only if they had an absolute macular scotoma including the fovea.

Results: : MRS is significantly smaller for dry eyes than for wet eyes even when adjusting for the clinical factors collected in our study: it is smaller (-31 %) in a model where only significant main effects are included. A consistent interaction, although only marginally significant, is found between the wet/dry and fPRL location factors: notably, the wet/dry difference is smaller for the left-field fPRL than for the lower-field fPRL. In addition, the predominant fPRL is in the lower field for wet eyes whereas it is in the left field for dry eyes.

Conclusions: : The large wet/dry difference in MRS cannot be accounted for by any of the factors measured in our work. However, the interaction with the fPRL factor suggests that reading strategies are more optimal for wet patients. The wet/dry difference might be related to the different time-courses of disease progression in each AMD type (sudden onset for wet disease vs. slow evolution for dry disease).

Keywords: age-related macular degeneration • reading 
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