April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Human Placenta Stem Cells as Potential Neuroprotective Mediators for the Treatment of Degenerative Retinopathy
S. Z. Scalinci; L. Scorolli; F. Alviano; G. Lanzoni; R. Costa; C. Marchionni; L. Bonsi; G. Bagnara; P. Tazzari; L. Calzà
Author Affiliations & Notes
  • S. Z. Scalinci
    Ophthalmology, University of Bologna SOrsola Malpighi, Bologna, Italy
    Department of Surgery and Transplants,, Centro di Studio per l'Ipovisione, University of Bologna - Bologna, Italy
  • L. Scorolli
    Ophthalmology, University of Bologna SOrsola Malpighi, Bologna, Italy
    Department of Surgery and Transplants,, Centro di Studio sul Glaucoma, University of Bologna - Bologna, Italy
  • F. Alviano
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • G. Lanzoni
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • R. Costa
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • C. Marchionni
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • L. Bonsi
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • G. Bagnara
    Department of Histology, Embriology and Applied Biology, University of Bologna - Bologna, Italy
  • P. Tazzari
    Immunohaematology and Transfusion Medicine Service, S. Orsola Malpighi Hospital, University of Bologna - Bologna, Italy
  • L. Calzà
    BioPharmaNet-DIMORFIPA, University of Bologna - Bologna, Italy
  • Footnotes
    Commercial Relationships  S.Z. Scalinci, None; L. Scorolli, None; F. Alviano, None; G. Lanzoni, None; R. Costa, None; C. Marchionni, None; L. Bonsi, None; G. Bagnara, None; P. Tazzari, None; L. Calzà, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3158. doi:
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      S. Z. Scalinci, L. Scorolli, F. Alviano, G. Lanzoni, R. Costa, C. Marchionni, L. Bonsi, G. Bagnara, P. Tazzari, L. Calzà; Human Placenta Stem Cells as Potential Neuroprotective Mediators for the Treatment of Degenerative Retinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3158.

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Abstract

Purpose: : Placenta derived stem cells display intriguing features like phenotypic plasticity and immunomodulatory properties. More recently they have been proposed as "factories" of cytokines, growth factors and anti-apoptotic factors. In this study we investigated in placenta-derived stem cells the expression of neurotrophic and neuroprotective factors with a potential for the treatment of degenerative retinopathy.

Methods: : Stem cells were isolated from amniotic membrane, chorion leave and Wharton’s Jelly. The populations were extensively characterized through flow cytometry analysis and assessed for multidifferentiation potential. Gene expression profile was studied with regard to nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and glial derived neurotrophic factor (GDNF).

Results: : Placenta derived stem cells displayed considerable in vitro expansion potential; they showed an immunophenotypical profile consistent with mesenchymal stem cells; in addition they underwent in vitro osteogenic, adipogenic and angiogenic commitment. Real-time PCR analysisevidenced notable expression levels of neurotrophic factors with differences related to the source. Wharton’s jelly and chorion cultures showed respectively the highest expression of BDNF and CNTF.

Conclusions: : In the degenerative context of retinopathy, the retinal photoreceptive epithelium could benefit from the neuroprotective effect of neurotrophic factors released by placenta stem cells. In vivo experiments in a mouse model of retinopathy are underway.

Keywords: retinal degenerations: cell biology • apoptosis/cell death • growth factors/growth factor receptors 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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