April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Second Generation Trabecular Meshwork Bypass Stent Increases Outflow Facility in Cultured Human Anterior Segments
Author Affiliations & Notes
  • C. K. Bahler
    Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • T. Fjield
    Glaukos Corporation, Laguna Hills, California
  • C. R. Hann
    Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • D. Haffner
    Glaukos Corporation, Laguna Hills, California
  • H. Heitzmann
    Glaukos Corporation, Laguna Hills, California
  • M. P. Fautsch
    Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • Footnotes
    Commercial Relationships  C.K. Bahler, Grant from Glaukos Corporation, F; Travel reimbursement, R; T. Fjield, Employee of Glaukos, E; Inventor/developer at Glaukos, P; C.R. Hann, Grant from Glaukos Corporation, F; D. Haffner, Employee of Glaukos, E; Inventor/developer at Glaukos, P; H. Heitzmann, Employee of Glaukos, E; Inventor/developer at Glaukos, P; M.P. Fautsch, Grant from Glaukos Corporation, F; Travel reimbursement, R.
  • Footnotes
    Support  Grant from Glaukos Corporation
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3240. doi:https://doi.org/
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      C. K. Bahler, T. Fjield, C. R. Hann, D. Haffner, H. Heitzmann, M. P. Fautsch; Second Generation Trabecular Meshwork Bypass Stent Increases Outflow Facility in Cultured Human Anterior Segments. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3240. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine whether a new second-generation bypass stent can increase outflow facility in cultured human anterior segments.

Methods: : Human anterior segments (n=5) were placed in perfusion organ culture. After stabilization in culture and establishment of a baseline pressure, the anterior segment was removed from culture and one or two stents were inserted into the trabecular meshwork from the posterior side within the nasal quadrant using a specially designed applicator. Following stent placement, anterior segments were returned to culture and perfused. Morphology of the trabecular meshwork and Schlemm’s canal were assessed by light and scanning electron microscopy.

Results: : Insertion of one stent into the nasal quadrant of the trabecular meshwork increased outflow facility from 0.17 ± 0.04 to 0.48 ± 0.33 µL/min/mmHg (p=0.063, n=5). Addition of a second stent further increased outflow facility to 0.83 ± 0.59 µL/min/mmHg (n=2). Scanning electron microscopy showed the thorax of the stent securely inserted within the trabecular meshwork while the head of the stent was located within the lumen of Schlemm’s canal. Minimal endothelial disruption was observed on Schlemm’s canal outer wall.

Conclusions: : Insertion of one or two stents into the trabecular meshwork increased outflow facility with minimal disruption of the outer wall cells that line Schlemm’s canal.

Keywords: outflow: trabecular meshwork • trabecular meshwork • intraocular pressure 
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