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K. Ogino, H. Nakamura, A. Tsujikawa, K. Miyamoto, T. Murakami, A. Sakamoto, M. Ohta, N. Yoshimura; Focal Macular Electroretinogram in Macular Edema Secondary to Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3260.
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© ARVO (1962-2015); The Authors (2016-present)
Many investigators have reported full field electroretinogram (ffERG) in retinal vein occlusion (RVO), so far, no information is available about the focal macular electroretinogaram (fmERG) in RVO. The purpose of this study is to evaluate the change of fmERG in macular edema (ME) secondary to RVO.
FmERG was recorded in 21 eyes with untreated unilateral branch retinal vein occlusion (BRVO), 13 eyes with untreated unilateral central retinal vein occlusion (CRVO), and 19 eyes of age-adjusted normal patients. The fmERG was elicited by a 15°circular white stimulus spot in CRVO, and by 15°circular, upper hemi-, and lower hemi-circular spots in BRVO and normal eyes. The luminance, duration, and rate of stimulus light were 181.5 cd/m2 , 150 ms, and 2 Hz, respectively. The luminance of back light was 6.9 cd/m2. The amplitude and implicit time of a-, b-wave, photopic negative response (PhNR) were analyzed as parametric data.
Reliable fmERGs could not be recorded in 2 afffected eyes of BRVO, 2 affetced and 2 fellow eyes of CRVO. Non-recordable ERGs were found in 2 affected eyes of CRVO, 5 affected hemi-circular sides and 1 fellow hemi-circular side of affected eyes of BRVO. The amplitudes of a-wave(0.7±0.5µV), b-waves(1.3±0.6µV) were significantly reduced and the implicit time were prolonged in affected eyes of CRVO relative to fellow eyes, and the amplitudes of all waves (a-wave1.1±0.4, b-wave2.6±0.8, PhNR1.7±0.8µV) were also reduced in fellow eyes of CRVO relative to control eyes. The amplitudes and implicit time of all waves(a-wave0.9±0.3, b-wave1.6±0.7, PhNR1.3±0.7µV) were significantly reduced and prolonged in affected eyes of BRVO relative to fellow eyes, and the amplitudes of a-waves(1.4±0.5µV), PhNR(2.1±0.8µV) were also reduced in fellow eyes of BRVO relative to control eyes. The amplitude of b-wave and the implicit time of a-wave were significantly changed in affected hemi-circular side of BRVO relative to fellow hemi-circular side.
In more than 80% of RVO, reliable fmERGs were recorded, and their features were reasonable to macular function of ME secondary to RVO. We suppose that this method is able to be one of the functional examinations of RVO.
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