April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Functional and Structural Changes of Retina in Amblyopic Eyes
Author Affiliations & Notes
  • G. Ozge
    Ophthalmology, GATA, Ankara, Turkey
  • F. C. Gundogan
    Ophthalmology, GATA, Ankara, Turkey
  • U. Erdem
    Ophthalmology, GATA, Ankara, Turkey
  • G. Sobaci
    Ophthalmology, GATA, Ankara, Turkey
  • Footnotes
    Commercial Relationships  G. Ozge, None; F.C. Gundogan, None; U. Erdem, None; G. Sobaci, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3280. doi:
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    • Get Citation

      G. Ozge, F. C. Gundogan, U. Erdem, G. Sobaci; Functional and Structural Changes of Retina in Amblyopic Eyes. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3280.

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Abstract

Purpose: : To explore the functional and structural changes in the retinas of amblyopic eyes.

Methods: : Seventeen unilateral amblyopic patients were included. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) tests were performed on both amblyopic and nonamblyopic eyes of the patients with Roland Consult-RetiScanTM system. Retinal sensitivity of retina was assessed by using mean deviation (MD) of Humphrey visual field test. The retinal nerve fiber layer thickness (RNFL) and central macular thickness (CMT) were measured by optical coherence tomography (OCT, StratusTM).

Results: : The mean ages of patients was 22±2,4. In PERG, P50 and N95 amplitudes were significantly reduced in amblyopic eyes (p<0.001, for both). There was no significant difference in P50 and N95 latencies between amblyopic and nonamblyopic eyes (p>0.05, for both). In PVEP, P100 amplitudes were significantly reduced (p=0.005); but, P100 latency values did not differ between amblyopic and nonamblyopic eyes (p=0.554). Mean RNFL thickness, nasal quadrant RNFL thickness and CMT were significantly increased in amblyopic eyes (p=0.006, p=0,005 and p<0.001, respectively). The retinal sensitivity was significantly higher in amblyopic eyes (p=0.002). This was more evident in the foveolar thresholds (p<0.001). P1 amplitudes in central 2.3 degree of mfERG were significantly lower in amblyopic eyes (p=0.017).

Conclusions: : Functional and structural changes of retina may occur in amblyopic eyes beside classically seen central supression in PVEP. The retinal structural changes in the amblyopic eyes may be a compensatory mechanism due to the decreased macular visual stimulation.

Keywords: amblyopia • electrophysiology: clinical • nerve fiber layer 
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