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T. P. Kislan, M. M. Hom; Corneal Infiltrates With Multipurpose Solutions and Contact Lens Combinations. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3424.
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To report the incidence of corneal infiltrates over one year with various combinations of multipurpose solutions (MPS) and contact lenses seen in a contact lens practice.
Chart review of 54 CL patients who presented with acute pain, redness, photophobia, corneal infiltrates and decreased VA.
Infiltrates appeared were central and numerous. 20 eyes (18.5%) had visual acuity loss of 20/40 or greater with 6 or more infiltrates and conjunctival redness grade 2+. 6 eyes (6.4%) had 2+ anterior chamber reactions with 3 or more infiltrates. Of the 54 patients, 83.3% (45/54) were using Alcon’s OptiFree RepleniSH, 11.1% (6/54) were using Bausch and Lomb’s Renu Multiplus, and 5.5% (3/54) were using AMO’s Complete Easy Rub. Overall, 64.8% (35/54) were using both ReplenisH MPS and Senofilcon A contact lens. Signs and symptoms resolved with corticosteroids and artificial tears.
Previous studies report higher incidence of corneal inflammatory events: senofilcon A over lotrafilcon B and polyquad over PHMB. The case series suggests that certain combinations of lenses and multipurpose solutions may be associated with increased incidence of corneal infiltrates.
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