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A. Denoyer, D. Godefroy, A. Grise, J. Frugier, F. Baudouin, W. Rostène, C. Baudouin; CX3CR1 Is Involved in the Ocular Surface Inflammation in vitro and in an Animal Model of Preservative-Induced Toxicity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3440.
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To investigate whether the chemokine receptor CX3CR1 could influence the inflammatory cell trafficking during ocular surface inflammation induced by an exposure to benzalkonium chloride (BAC).
Leukocyte chemotaxis was observed when HCCs are stimulated with BAC. Human monocytic cells (CD45+,CD14+) and NK cells (CD45+,CD56+,CD3-) migration was inhibited by blocking the CX3CR1 receptor. In a mouse model of BAC-induced ocular surface toxicity, the inflammatory cell infiltration of the conjunctiva was altered in the CX3CR1 KO mice compared to wild-type.
Activation of the chemokine receptor CX3CR1 is involved in the BAC-induced conjunctival inflammation. Specific blockade of this receptor could regulate the cell trafficking in the ocular surface.
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