April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
CX3CR1 Is Involved in the Ocular Surface Inflammation in vitro and in an Animal Model of Preservative-Induced Toxicity
Author Affiliations & Notes
  • A. Denoyer
    Prof C Baudouin, XV-XX Natl Ophthalmology Hosp, Paris, France
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • D. Godefroy
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • A. Grise
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • J. Frugier
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • F. Baudouin
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • W. Rostène
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • C. Baudouin
    Prof C Baudouin, XV-XX Natl Ophthalmology Hosp, Paris, France
    Team 8, Vision Institute, UMRS968, INSERM UPMC, Paris, France
  • Footnotes
    Commercial Relationships  A. Denoyer, None; D. Godefroy, None; A. Grise, None; J. Frugier, None; F. Baudouin, None; W. Rostène, None; C. Baudouin, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3440. doi:
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      A. Denoyer, D. Godefroy, A. Grise, J. Frugier, F. Baudouin, W. Rostène, C. Baudouin; CX3CR1 Is Involved in the Ocular Surface Inflammation in vitro and in an Animal Model of Preservative-Induced Toxicity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3440.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate whether the chemokine receptor CX3CR1 could influence the inflammatory cell trafficking during ocular surface inflammation induced by an exposure to benzalkonium chloride (BAC).

Methods: : In vitro

Results: : Leukocyte chemotaxis was observed when HCCs are stimulated with BAC. Human monocytic cells (CD45+,CD14+) and NK cells (CD45+,CD56+,CD3-) migration was inhibited by blocking the CX3CR1 receptor. In a mouse model of BAC-induced ocular surface toxicity, the inflammatory cell infiltration of the conjunctiva was altered in the CX3CR1 KO mice compared to wild-type.

Conclusions: : Activation of the chemokine receptor CX3CR1 is involved in the BAC-induced conjunctival inflammation. Specific blockade of this receptor could regulate the cell trafficking in the ocular surface.

Keywords: inflammation • conjunctiva • ocular irritants 
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