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H. Barash, Z. Burgansky-Eliash, D. Izhaky, D. A. Nelson, A. Barak, A. Loewenstein, A. Grinvald; Blood Flow Velocity in Branch Vein Occlusion Patients. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3447.
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© ARVO (1962-2015); The Authors (2016-present)
To measure blood flow velocity non-invasively in the perifoveal vessels of patients with branch retinal vein occlusion (BRVO) and compare between occluded and non-occluded vessels.
Eight eyes of 7 patients and 8 eyes of age-matched healthy subjects were recruited. All patients were scanned by the Retinal Function Imager (RFI, Optical Imaging, Ltd) with analysis of blood flow velocity of secondary and tertiary branches of arteries and veins. Comparison between groups was done using student t-test. A paired t-test was performed comparing the velocity in the venules of the occluded (whether completely occluded and draining to the opposite system or resolved and draining into the original venous flow direction) and non-occluded venous branches.
The average velocity in the terminal arterioles was significantly slower in the BRVO patients compared to healthy subjects (3.6±0.9 vs. 4.6±1.2 mm/sec; p < 0.05). The velocity in larger arterioles displayed the same, but not significant, trend (3.8±0.9 vs. 4.8±1.4 mm/sec). We were able to observe reversed flow in unresolved occlusions to collaterals. In addition, the velocity in the venules of the occluded branch was significantly slower than in the non-occluded branch in both resolved and unresolved occlusions (2.3±0.8 vs. 2.8±0.7 mm/sec; p < 0.05).
This small cohort of BRVO patients demonstrated slower arterial retinal blood flow velocity compared to healthy subjects. We were able to non-invasively compare the velocity between the different retinal vein branches and to demonstrate the reverse flow in collaterals. The RFI may offer a tool for BRVO assessment, follow-up and treatment.
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