April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Simultaneous High Resolution SLO/OCT Imaging With a Multimodal Adaptive Optics Retinal Imager
Author Affiliations & Notes
  • D. X. Hammer
    Physical Sciences Inc, Andover, Massachusetts
  • D. Ferguson
    Physical Sciences Inc, Andover, Massachusetts
  • M. Mujat
    Physical Sciences Inc, Andover, Massachusetts
  • A. H. Patel
    Physical Sciences Inc, Andover, Massachusetts
  • E. E. Plumb
    Physical Sciences Inc, Andover, Massachusetts
  • N. Iftimia
    Physical Sciences Inc, Andover, Massachusetts
  • N. J. Coletta
    Department of Vision Science, New England College of Optometry, Boston, Massachusetts
  • J. D. Akula
    Ophthalmology, Children's Hospital, Boston, Massachusetts
  • A. B. Fulton
    Ophthalmology, Children's Hospital, Boston, Massachusetts
  • Footnotes
    Commercial Relationships  D.X. Hammer, Physical Sciences Inc., E; Physical Sciences Inc., P; D. Ferguson, Physical Sciences Inc., P; Physical Sciences Inc., E; M. Mujat, Physical Sciences Inc., E; Physical Sciences Inc., P; A.H. Patel, Physical Sciences Inc., E; E.E. Plumb, Physical Sciences Inc., E; N. Iftimia, Physical Sciences Inc., E; Physical Sciences Inc., P; N.J. Coletta, None; J.D. Akula, None; A.B. Fulton, None.
  • Footnotes
    Support  NIH Grant EY018986
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3455. doi:
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      D. X. Hammer, D. Ferguson, M. Mujat, A. H. Patel, E. E. Plumb, N. Iftimia, N. J. Coletta, J. D. Akula, A. B. Fulton; Simultaneous High Resolution SLO/OCT Imaging With a Multimodal Adaptive Optics Retinal Imager. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3455.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To develop a multimodal adaptive optics (AO) retinal imaging system that provides simultaneous high resolution spectral domain optical coherence tomography (SDOCT) and scanning laser ophthalmoscopy (SLO) imaging capabilities in both humans and small animals.

 
Methods:
 

A high performance AO retinal imager was designed, constructed, and tested on human subjects without retinal disease. The system includes AO-corrected SDOCT and SLO channels, wide field line scanning ophthalmoscope (LSO), integrated retinal tracker (RT), and small animal imaging port. The AO components include two deformable mirrors for clinical correction of a wide spectrum of ocular aberrations. The scanners are ordered and processing hardware designed such that high-resolution SLO, OCT, and wavefront sensor (WS) images are collected simultaneously and synchronously, while the LSO and RT run simultaneously but asynchronously. The optical design includes an integrated small animal port that switched, with one flip-mounted optic, between output pupil diameters of 7.5 mm (for humans) and 2.5 mm (for small animals). The imaging field of regard is ~30 deg. The SLO, OCT, LSO, and RT beams are respectively centered at 760, 850, 915, and 1060 nm. A liquid crystal display is also included for fixation target and stimulus presentation.

 
Results:
 

The dual AO system significantly improved retinal image resolution and brightness for all six subjects tested. The multimodal imager provided a powerful complement of simultaneous live images in common retinal coordinates, including (a) LSO, (b) SLO, and (c) SDOCT as shown in the accompanying figure. In preliminary testing, photoreceptors could be resolved to within 0.5 deg. (100-150 µm) of the fovea.

 
Conclusions:
 

The new multimodal AO system with simultaneous imaging modes is a powerful real time platform capable of resolving the finest structural details in the retina.  

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
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