Purchase this article with an account.
D. X. Hammer, D. Ferguson, M. Mujat, A. H. Patel, E. E. Plumb, N. Iftimia, N. J. Coletta, J. D. Akula, A. B. Fulton; Simultaneous High Resolution SLO/OCT Imaging With a Multimodal Adaptive Optics Retinal Imager. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3455.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To develop a multimodal adaptive optics (AO) retinal imaging system that provides simultaneous high resolution spectral domain optical coherence tomography (SDOCT) and scanning laser ophthalmoscopy (SLO) imaging capabilities in both humans and small animals.
A high performance AO retinal imager was designed, constructed, and tested on human subjects without retinal disease. The system includes AO-corrected SDOCT and SLO channels, wide field line scanning ophthalmoscope (LSO), integrated retinal tracker (RT), and small animal imaging port. The AO components include two deformable mirrors for clinical correction of a wide spectrum of ocular aberrations. The scanners are ordered and processing hardware designed such that high-resolution SLO, OCT, and wavefront sensor (WS) images are collected simultaneously and synchronously, while the LSO and RT run simultaneously but asynchronously. The optical design includes an integrated small animal port that switched, with one flip-mounted optic, between output pupil diameters of 7.5 mm (for humans) and 2.5 mm (for small animals). The imaging field of regard is ~30 deg. The SLO, OCT, LSO, and RT beams are respectively centered at 760, 850, 915, and 1060 nm. A liquid crystal display is also included for fixation target and stimulus presentation.
The dual AO system significantly improved retinal image resolution and brightness for all six subjects tested. The multimodal imager provided a powerful complement of simultaneous live images in common retinal coordinates, including (a) LSO, (b) SLO, and (c) SDOCT as shown in the accompanying figure. In preliminary testing, photoreceptors could be resolved to within 0.5 deg. (100-150 µm) of the fovea.
The new multimodal AO system with simultaneous imaging modes is a powerful real time platform capable of resolving the finest structural details in the retina.
This PDF is available to Subscribers Only