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T. Realini, R. N. Weinreb, S. Wisniewski; Diurnal Intraocular Pressure Patterns Are Not Repeatable in the Short Term in Glaucomatous Individuals. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3492.
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To evaluate the short-term repeatability of diurnal intraocular pressure (IOP) patterns in eyes with primary open-angle glaucoma (POAG).
47 subjects with treated POAG underwent assessment of IOP using Goldmann tonometry every two hours from 0800 to 2000 on two visits one week apart. Inter-visit agreement of IOP by time point and IOP change between time points was assessed using intraclass correlation coefficients (ICC).
Between-visit agreement of IOP values at each time point was generally fair to good, with ICCs ranging from 0.45 to 0.71 in right eyes and from 0.51 to 0.71 in left eyes. Between-visit agreement of IOP change over time periods between time points was uniformly poor and occasionally below that expected by chance alone, with ICCs ranging from -0.08 to 0.38 in right eyes and from -0.11 to 0.36 in left eyes.
Treated POAG patients do not manifest a repeatable diurnal IOP pattern from day to day when measured by Goldmann tonometry. Measurement of single-day IOP variation poorly characterized short-term IOP variation.
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