April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Diurnal Intraocular Pressure Patterns Are Not Repeatable in the Short Term in Glaucomatous Individuals
Author Affiliations & Notes
  • T. Realini
    Ophthalmology, WVU Eye Institute, Morgantown, West Virginia
  • R. N. Weinreb
    Hamilton Glaucoma Center, Univ of California-San Diego, La Jolla, California
  • S. Wisniewski
    Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  T. Realini, None; R.N. Weinreb, None; S. Wisniewski, None.
  • Footnotes
    Support  Supported by National Institutes of Health Grants EY015682 (TR) and EY018859 (TR) and by an unrestricted grant from Research to Prevent Blindness (WVU).
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3492. doi:
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      T. Realini, R. N. Weinreb, S. Wisniewski; Diurnal Intraocular Pressure Patterns Are Not Repeatable in the Short Term in Glaucomatous Individuals. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3492.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the short-term repeatability of diurnal intraocular pressure (IOP) patterns in eyes with primary open-angle glaucoma (POAG).

Methods: : 47 subjects with treated POAG underwent assessment of IOP using Goldmann tonometry every two hours from 0800 to 2000 on two visits one week apart. Inter-visit agreement of IOP by time point and IOP change between time points was assessed using intraclass correlation coefficients (ICC).

Results: : Between-visit agreement of IOP values at each time point was generally fair to good, with ICCs ranging from 0.45 to 0.71 in right eyes and from 0.51 to 0.71 in left eyes. Between-visit agreement of IOP change over time periods between time points was uniformly poor and occasionally below that expected by chance alone, with ICCs ranging from -0.08 to 0.38 in right eyes and from -0.11 to 0.36 in left eyes.

Conclusions: : Treated POAG patients do not manifest a repeatable diurnal IOP pattern from day to day when measured by Goldmann tonometry. Measurement of single-day IOP variation poorly characterized short-term IOP variation.

Keywords: intraocular pressure • circadian rhythms • clinical (human) or epidemiologic studies: natural history 

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