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Y. Liang, D. S. Friedman, Q. Zhou, L. Guo, N. Wang, L. Sun, Y. Peng, D. Chang, T. Y. Wong; A Population-Based Assessment of Diurnal Intraocular Pressure Among Subjects With Primary Open Angle Glaucoma: The Handan Eye Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3495.
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© ARVO (1962-2015); The Authors (2016-present)
Purposes: To describe the distribution of the diurnal intraocular pressure (IOP) among subjects with primary open angle glaucoma (POAG) in a population-based study in rural north China.
6,830 subjects (90.4% of 7577 eligible) of Chinese (Han ethnicity) aged 30+ years participated the Handan Eye Study, 115 of whom had POAG. 84 of them (73.0%) attended a follow up study in which IOP was tested with a Perkins handheld applanation tonometer at 10 am, 2pm, 6pm, 10pm, 2am, and 6am. For persons with unilateral glaucoma, the eye with glaucoma was studied, while for those with glaucoma in both eyes, the eye with the higher IOP was studied.
41 of the 84 subjects (49%) had glaucoma in both eyes. Of the 84 selected eyes, 15 (17.9%) had at least one IOP greater than 21mmHg, 13 (86.7%) of which occurred in the morning at 6am or 10am. The mean diurnal IOP was 15.0±3.0 mmHg and the fluctuation range was 5.3±2.1 mmHg. No significant differences were found in mean diurnal IOP or IOP fluctuation when comparing the glaucomatous eye to the non-glaucomatous eye in persons with unilateral glaucoma. None of subjects was taking ocular hypotensive agents.
Persons with glaucoma in this population-based study typically had eye pressures below 22 mmHg even after diurnal testing. The similarity of diurnal IOP between glaucoma eyes and contralateral non glaucoma eyes suggests that factors other than IOP may play a role in the development of glaucomatous optic neuropathy in some of these persons.
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