April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Sclerosing Orbital Inflammation and Systemic Disease
Author Affiliations & Notes
  • B. J. Winn
    Ophthalmology, Columbia University, New York, New York
  • J. Rootman
    Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada
  • Footnotes
    Commercial Relationships  B.J. Winn, None; J. Rootman, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3530. doi:
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      B. J. Winn, J. Rootman; Sclerosing Orbital Inflammation and Systemic Disease. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3530.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To determine the clinical differences between sclerosing orbital inflammation (SOI) isolated to the orbit and SOI manifesting as multifocal fibrosclerosis (MFF) when associated with retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, and/or Riedel’s thyroiditis. While large studies of isolated SOI have found that it is essentially a unilateral disease with no sex predilection, most often affecting people in their 30s to 50s, no large studies of MFF-related SOI have been performed due to its rarity.

Methods: : Case Series:

Results: : Case series:

Conclusions: : SOI in the setting of MFF is often bilateral and associated with an elevated ESR. As orbital disease may precede or coincide with extra-orbital involvement, investigations including chest and abdominal imaging, liver and kidney function tests, ESR and thyroid stimulating hormone should be obtained in cases of SOI to identify potentially life-threatening systemic involvement.

Keywords: orbit • autoimmune disease • inflammation 

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