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S. Wang, L. Xu, J. Jonas, Y. Wang, Q. You, H. Yang; Five Years Incidence and Prognosis of Retinal Microvascular Abnormalities and Their Associations With Arterial Hypertansion in Non-Diabetes Population. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3534.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the retinal microvascular abnormalities in rural and urban Beijing in 2001 and 2006, to observe the incidence and prognosis of retinal microvascular abnormalities, to analyse their associations with arterial hypertension in non-diabetes population.
The Beijing Eye Study, a population-based study in Beijing defined population, was registered 5324 subjects who were 40 years old or more, in which 4439 (83.4%) subjects attended in the baseline examination in 2001. 3251 (75.7%) survival subjects attended in the following-up examination in 2006. In baseline examination and following-up examination, questionnaires and detail ophthalmological examinations were conducted in every attended subjects. Color photographys of fundus were morphometrically assessed. Focal retinal arteriolar narrowing (FN), arteriovenous nicking (AV nicking), and retinopathy were assessed using qualitative methods.
The five-year accumulated incidence of FN, AV nicking, and retinopathy were 4.1%, 1.4%, and 3.3%, respectively. The incidence of ratinopathy was significantly increased in rural (4.3%), comparing with in urban (2.5%, P=0.006); Controlled by other risk factors, every 10 mmHg mean arterial blood pressure (MABP) increasing, the risks of incidences of FN, AV nicking and retinopathy were increased 58%, 55%, and 46%; the regress possibilities of FN decreased 28%. Controlled by other risk factors, in hypertensive patients, comparing with controlled group, the risk of the incidence of FN, AV nicking, and retinopathy in uncontrolled group increased 71%, 1.1 times, and 1.3 times, respectively; the risk of the incidence of FN, AV nicking, and retinopathy in untreated group increased 1.6 times, 2.1 times,and 2.3 times; the regress possibilities of FN in uncontrolled and untreated group were descresed 69% and 87%.
Arterial hypertension is the most important systemic cause of retinal microvascular abnormalities in population without diabetes. Controlled hypertension can decrease the risk of the incidence of retinal microvascular abnormalities in hypertensive patients, and can benefit the regress of retinal vascular functional damages in early stage, such as focal retinal arteriolar narrowing.
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