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L. de Polo, M. Cigada, G. Staurenghi; Visual Improvement in Central Retinal Vein Occlusion (crvo) Following Intravitrel Injections of Bevacizumab. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3571.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the visual acuity improvement inresponse to intravitreal injections of bevacizumab in central retinal vein occlusion (CRVO).
Retrospective consecutive non comparative case series of 22 eyes of 22 patients affected by CRVO were enrolled; mean age was 64 years (range 43-85 years);10 males and 12 females. At baseline ETDRS mean visual acuity was 20/100 (range 20/400-20/40). No previous treatment occured. A complete clinical examination, including optical coherence tomography (OCT), was carried out at baseline and after each injection of bevacizumab and at all follow-up visits. Digital fluorescein angiography (HRA) was performed at baseline and each 6 months. Mean number of injections was 3.5 (range1-12) during a mean follow-up of 28 months (range 12-41). Intra-vitreal injections of bevacizumab (1.25 mg/ 0.05 ml) were given at baseline and after OCT retinal Thickness increase or visual acuity reduction.
Final ETDRS mean visual acuity was 20/50 (range 20/200-20/20).Visual acuity improvement was less than 15 ETDRS letters for 55% of patients and more than 15 ETDRS letters for 45% of patients. No visual acuity reduction occured. A Fisher’s Exact Test for Count Data demonstrates that the frequency, the number of injections and the follow-up lenght are not statistical significant to demonstrate a visual improvement. Using the Analysis of Variance (ANOVA) the baseline value of visual acuity has a statistically significant effect on visual acuity (P=0.03). No adverse events occured.
In response to intravitreal injections of bevacizumab during 28 months, a statistically significant improvement in visual acuity occurs depending to the baseline visual acuity and it is independent from the number and the frequency of injections. Further clinical trials are needful to evaluate a larger number of patients and a longer follow-up.
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