April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Cross-Linked Hyaluronic Acid as Vitreous Replacment - In vivo Biocompatibility
Author Affiliations & Notes
  • M. S. Spitzer
    Ophthalmology, Tuebingen University Eye Center, Tuebingen, Germany
  • C. Frank
    Ophthalmology, University Eye Hospital Tuebingen, Tuebingen, Germany
  • M. Warga
    Ophthalmology, Tuebingen University Eye Center, Tuebingen, Germany
  • E. Yoeruek
    Ophthalmology, Tuebingen University Eye Center, Tuebingen, Germany
  • M. Schultheiss
    Ophthalmology, Tuebingen University Eye Center, Tuebingen, Germany
  • K. U. Bartz-Schmidt
    Ophthalmology, Tuebingen University Eye Center, Tubingen, Germany
  • P. Szurman
    Ophthalmology, Tuebingen University Eye Center, Tuebingen, Germany
  • Footnotes
    Commercial Relationships  M.S. Spitzer, None; C. Frank, None; M. Warga, None; E. Yoeruek, None; M. Schultheiss, None; K.U. Bartz-Schmidt, None; P. Szurman, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3596. doi:
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      M. S. Spitzer, C. Frank, M. Warga, E. Yoeruek, M. Schultheiss, K. U. Bartz-Schmidt, P. Szurman; Cross-Linked Hyaluronic Acid as Vitreous Replacment - In vivo Biocompatibility. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3596.

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Abstract

Purpose: : To test the biocompatibility and long-term stability of cross-linked hyaluronic acid biopolymers as vitreous replacement in rabbit eyes.

Methods: : Hyaluronic acid was cross-linked using a modified protocol. The vitreous was removed by pars plana vitrectomy in 10 rabbit eyes and replaced by injection of the cross-linked biogels. ERG, slit lamp examination, funduscopy and measurement of intraocular pressure were performed at regular intervals postoperatively. The eyes were enucleated 4 to 10 weeks after surgery and histology was assessed for signs of cytotoxicity.

Results: : The Biogels could be injected without complications via the pars plans using 20 gauge cannulas. There were no signs of intraocular inflammation and intraocular pressure was normal during the entire postoperative period. Electrophysiology, histology and immunohistochemistry demonstrated an excellent tissue biocompatibility. The biogels remained in place for up to 10 weeks without losing optical clarity or elasticity.

Conclusions: : The results demonstrate the general feasibility and biocompatibility of cross-linked hyaluronic acid biopolymers as vitreous replacement

Keywords: vitreous substitutes • vitreoretinal surgery • vitreous 
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