Purchase this article with an account.
M. S. Spitzer, C. Frank, M. Warga, E. Yoeruek, M. Schultheiss, K. U. Bartz-Schmidt, P. Szurman; Cross-Linked Hyaluronic Acid as Vitreous Replacment - In vivo Biocompatibility. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3596.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To test the biocompatibility and long-term stability of cross-linked hyaluronic acid biopolymers as vitreous replacement in rabbit eyes.
Hyaluronic acid was cross-linked using a modified protocol. The vitreous was removed by pars plana vitrectomy in 10 rabbit eyes and replaced by injection of the cross-linked biogels. ERG, slit lamp examination, funduscopy and measurement of intraocular pressure were performed at regular intervals postoperatively. The eyes were enucleated 4 to 10 weeks after surgery and histology was assessed for signs of cytotoxicity.
The Biogels could be injected without complications via the pars plans using 20 gauge cannulas. There were no signs of intraocular inflammation and intraocular pressure was normal during the entire postoperative period. Electrophysiology, histology and immunohistochemistry demonstrated an excellent tissue biocompatibility. The biogels remained in place for up to 10 weeks without losing optical clarity or elasticity.
The results demonstrate the general feasibility and biocompatibility of cross-linked hyaluronic acid biopolymers as vitreous replacement
This PDF is available to Subscribers Only