April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Retinal-Specific Measurement of Dark Adapted Visual Function Using the Mp-1 Microperimeter
Author Affiliations & Notes
  • M. D. Crossland
    Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom
    NIHR BMRC for Ophthalmology, London, United Kingdom
  • V. A. Luong
    Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom
  • G. S. Rubin
    Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom
    NIHR BMRC for Ophthalmology, London, United Kingdom
  • F. W. Fitzke
    Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom
    NIHR BMRC for Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships  M.D. Crossland, None; V.A. Luong, None; G.S. Rubin, None; F.W. Fitzke, None.
  • Footnotes
    Support  NIHR grants PDF/01/2008/011 and BMRC 037
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3640. doi:https://doi.org/
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      M. D. Crossland, V. A. Luong, G. S. Rubin, F. W. Fitzke; Retinal-Specific Measurement of Dark Adapted Visual Function Using the Mp-1 Microperimeter. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3640. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Scotopic function is an important marker of many retinal diseases and is increasingly used as an outcome measure in clinical trials, such as those investigating gene therapy for Lebers congenital amaurosis. Scotopic visual function has traditionally been measured using an adapted perimetry system such as the Humphrey field analyser (HFA). However this system does not control for fixation errors or poor fixation stability. Here we evaluate the use of an adapted microperimeter to measure visual function at defined retinal regions under scotopic conditions.

Methods: : A MP-1 microperimeter (Nidek Technologies, Italy) was modified by adding a 1 log unit Neutral Density filter and a 530nm shortpass filter within the optical path of the instrument. Stray light was shielded. Fine matrix mapping perimetry was performed on five younger (65 years) subjects with no eye disease and good vision. All subjects were fully dark adapted before testing and pupils were dilated with 1% tropicamide. Tests was performed once on the modified MP-1 microperimeter and once using a modified HFA, in a counterbalanced order.

Results: : A foveal scotopic scotoma with a sensitivity reduction of >1 log unit was found using each instrument. In addition, the MP-1 system showed the retinal location of the foveal scotoma. Mean test time was 21 minutes for the MP-1 and 32 minutes for the HFA.

Conclusions: : A modified MP-1 microperimeter can be used to measure scotopic retinal function, creating results which are comparable to the modified Humphrey field analyser. Advantages of the MP-1 system include the ability to track the retina through testing, retinal localisation of the scotoma and a faster test time.

Keywords: perimetry • retina • visual fields 
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