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M. M. Abitbol; Role of Sirt1 and Sirt6 Expression in the Pathophysiology of the rd10 Mouse Retinal Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3650. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To study the expression of Sirt1 and Sirt6 and their links with DNA damage in the rd10 mouse retinal degeneration
We used immunohistochemistry, western blot, in situ hybridization,qRT-PCR for evaluating Sirt1 and Sirt6 expression as well as the occurence of DNA damage during the time course of the rd10 mouse retinal degeneration
We report the differential retinal expression of Sirt1 and Sirt6 as well that of DNA damage markers at different stages of the rd10 retinal degeneration and at the same stages of normal retinas in control C57BL6/J mice . The comparison between rd10 and C57BL6/J retinas suggest that Sirt1 and Sirt6 may act as neuroprotective agents in the normal retina
This study suggests that viral vectors overexpressiong Sirt1 or Sirt6 might be novel therapeutic agents for retinal degenerations. Similarly, chemical compounds activating Class 3 histone deacetylases might constitute anovel general strategy for delaying the time course or preventing the occurence of retinal degenerations
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