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M. Sasaki, Y. Ozawa, T. Kurihara, S. Kubota, K. Yuki, K. Noda, S. Kobayashi, S. Ishida, K. Tubota; Neuroprotective Effect of an Anti-Oxidant, Lutein, on Light-Induced Retinal Degeneration. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3690.
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To investigate the neuroprotective effect of lutein on retinal neural damage caused by photo-oxidative stress.
Mice were fed with laboratory chow with or without 0.1% lutein and exposed to 5,000 lux fluorescent light for 3 hours. Retinal damage was estimated by analyzing (1) number of TUNEL positive cells, (2) outer nuclear layer (ONL) thickness, and (3) retinal function was measured by electroretinography (ERG).
Light exposure induced increase in TUNEL positive cells in ONL, leading to the reduction of ONL thickness and a-wave amplitude in ERG, as previously reported. (1) However, lutein diet decreased the light-induced apoptosis in ONL by 43.7% of the control (p<0.01). (2) Consistently, Lutein diet significantly avoided the reduction of ONL thickness (p<0.05). (3) Furthermore, mice fed with lutein diet showed higher level of a-wave amplitude in ERG than those fed with control chow after light exposure (p<0.01).
Lutein contributed to preservation of better visual function by protecting photoreceptor cells from apoptosis after light exposure. Lutein has a neuroprotective effect in light-induced retinal degeneration.
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