April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Role of Systemic Investigations and Characteristic Ocular Signs for the Diagnosis of Ocular Sarcoidosis
Author Affiliations & Notes
  • F. Di Matteo
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • E. Miserocchi
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • G. Modorati
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • A. Colucci
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • L. Berchicci
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • F. Bandello
    Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy
  • Footnotes
    Commercial Relationships  F. Di Matteo, None; E. Miserocchi, None; G. Modorati, None; A. Colucci, None; L. Berchicci, None; F. Bandello, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3772. doi:
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      F. Di Matteo, E. Miserocchi, G. Modorati, A. Colucci, L. Berchicci, F. Bandello; Role of Systemic Investigations and Characteristic Ocular Signs for the Diagnosis of Ocular Sarcoidosis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3772.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the diagnostic values of systemic investigations and ocular signs in patients with biopsy-proven sarcoidosis.

Methods: : Forty-four patients with biopsy-proven ocular sarcoidosis and sixty-one control patients with other types of uveitis were included in this retrospective study. Frequencies of systemic investigation results (tubercolin skin test, serum angiotensin-converting enzyme, serum lysozime, and chest X-ray) and ocular signs (mutton fat keratic precipitates or iris nodules, trabecular meshwork nodules or peripheral anterior sinechia, snowball opacities or vitreitis, vasculitis, and chorioretinal lesions) were evaluated. We analyzed sensitivity, specificity, positive and negative predictive value for each single factor and for all the possible combinations.

Results: : The incidence of abnormal systemic investigation results, anterior segment signs and vitreous opacites were significantly higher in sarcoidosis patients than in patients with other types of uveitis; on the contrary, the frequencies of vasculitis and chorioretinal lesions were similar in the two groups. The presence of two abnormal systemic investigation results, and three anterior segment and vitreous signs, showed a high diagnostic value for ocular sarcoidosis, although sensitivity was below 0.6.

Conclusions: : In the study population, combinations of systemic investigations and clinical signs was a useful, although not highly sensitive, diagnostic tool for the identification of patients with ocular sarcoidosis.

Keywords: uveitis-clinical/animal model • autoimmune disease • uvea 
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