April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Long-Term Follow-Up of Patients With Dry Eye Associated With Chronic Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation
Author Affiliations & Notes
  • C. S. Sáles
    Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts
  • L. J. Johnston
    Stanford University, Stanford, California
  • C. N. Ta
    Stanford University, Stanford, California
  • Footnotes
    Commercial Relationships  C.S. Sáles, None; L.J. Johnston, None; C.N. Ta, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3773. doi:
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      C. S. Sáles, L. J. Johnston, C. N. Ta; Long-Term Follow-Up of Patients With Dry Eye Associated With Chronic Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3773.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To assess the long-term clinical course of dry eye in patients with chronic graft-versus-host disease (GVHD).

Methods: : A prospective case series of 49 patients with chronic GVHD was conducted. Complete history and ophthalmic examination were performed at baseline and at 36 months (Range, 26-53). All patients received treatment for dry eye.

Results: : Of the 49 patients, 31 (63%) were alive at the time of the 3-year eye examination. Eleven of the 31 patients were lost to follow-up, eleven declined or were unable to attend the final examination, and 9 patients completed the study. There was an overall improvement in subjective symptoms of dry eye assessed by the Ocular Surface Disease Index© (start vs. endpoint: 36 ± 22 [Range, 4-72] vs. 30 ± 27 [Range, 4-86]; P=0.51). Visual acuity remained stable at approximately 20/20. Lissamine green staining (LGS) improved and Schirmer’s test (with anesthetic) worsened, but neither trend was statistically or clinically significant.

Conclusions: : Patients with chronic GVHD may have a persistent clinical course of dry eye despite treatment. The long-term prognosis is likely characterized by stable visual acuity, tear production, and LGS, as well as improved quality of life.

Keywords: cornea: tears/tear film/dry eye • clinical (human) or epidemiologic studies: natural history • clinical (human) or epidemiologic studies: outcomes/complications 

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