April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Clinical and Pathologic Characteristics of Biopsy Proven Iris Melanomas: Results of a Multicenter International Study
Author Affiliations & Notes
  • S. Khan
    Ophthalmology, New York University, New York, New York
    New York Eye Cancer Center, New York, New York
  • P. T. Finger
    New York Eye Cancer Center, New York, New York
  • P. Sankull
    Ophthalmology, St. Erik Eye Hospital, Stockholm, Sweden
  • S. Seregard
    Ophthalmology, St. Erik Eye Hospital, Stockholm, Sweden
  • D. Gologorsky
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • T. Murray
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida
  • T. Kivela
    Ophthalmology, Helsinki University Central Hospital, New York, Finland
  • S. Eskelin
    Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland
  • R. Raut
    Ophthalmology, University of Montreal, Montral, QC
  • C. Corriveau
    Ophthalmology, University of Montreal, Montral, QC
  • Footnotes
    Commercial Relationships  S. Khan, None; P.T. Finger, None; P. Sankull, None; S. Seregard, None; D. Gologorsky, None; T. Murray, None; T. Kivela, None; S. Eskelin, None; R. Raut, None; C. Corriveau, None.
  • Footnotes
    Support  This work was supported by The EyeCare Foundation, Inc. New York City, (http://eyecarefoundation.org) and The AJCC-UICC Ophthalmic Oncology Task Force, http://eyecancerbig.org.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3808. doi:https://doi.org/
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      S. Khan, P. T. Finger, P. Sankull, S. Seregard, D. Gologorsky, T. Murray, T. Kivela, S. Eskelin, R. Raut, C. Corriveau; Clinical and Pathologic Characteristics of Biopsy Proven Iris Melanomas: Results of a Multicenter International Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3808. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To pool patient data from multiple centers to identify epidemiologic, clinical and pathologic characteristics of malignant melanoma of the iris (MMI).

Methods: : An internet-based program (Science StudyTrax, Florida) was created to allow for multicenter, international, online data entry. Multiple physician-authors at 5 centers from 4 countries performed retrospective chart reviews on patients with MMI. Specific outcome measures included: demographics, tumor characteristics, related ocular and angle abnormalities, 7th annual AJCC-UICC tumor staging, management options and outcomes.

Results: : Seventy-one patients from 5 centers were identified. 43 patients were female (63%). Mean age at diagnosis was 60 and median initial visual acuity was 20/20 (range 20/16 - 20/200). Majority were blue-eyed (n=48, 70%). Tumor color was coded brown (n=38, 53%), amelanotic (n=11,15%) and multicolored (n=7, 10%). Location noted as diffuse (n=3), multifocal (n=46, 65%). Mean number of clock hours involved was 1.9. Median central meridian at 5 o’clock. Mean largest clinical and ultrasonographic diameter was 5.1 mm. Mean UBM thickness was 2.0 mm (range 0 - 8.3mm). Intrinsic tumor vessels present in n=35 (51%) and an iris feeder vessel in (n=5) 7%. Tumors were multifocal (91%), irregular surfaced 55%, with correctopia 25%. Ultrasonographic angle blunting noted in 50%, iris root disinsertion 16%, and IPE displacement in 12%. Clinical presentation included (n=2, 3%) with AC inflammation, hyphema (n=2, 3%), glaucoma (n=13, 19%) and (n=5, 7%) with sectoral cataracts. Clinical TNM staging showed the majority (40%) of tumors classified were T1a (Limited to the iris- not more than 3 clock hours in size). Histologic grade was most spindle cell type (64%), mixed (12%), epithelioid in 4% and 20% had unidentified grading.

Conclusions: : This study presents results from the first multicenter, international internet-based study in ophthalmic oncology. We utilized a standard tumor grading system, pool data and extract information on a rare tumor. Bio-informatic cooperative studies allows ophthalmic oncology study larger and more significant numbers of rare tumors.

Keywords: iris • melanoma • oncology 
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