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A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, T. Oshika, Y. Yasuno; Tissue Contrast Imaging of Anterior Eye Based on Optical Properties Measured by Polarization Sensitive Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3853.
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© ARVO (1962-2015); The Authors (2016-present)
Although tissues of anterior eye have distinctive properties, they are not clearly contrasted by optical coherence tomography (OCT). We employed polarization sensitive OCT (PS-OCT), which measures biefringence of a sample, to discriminate the tissues. This paper aims at demonstrating tissue contrast tomographic imaging of anterior angle by using our newly developed PS-OCT and associate tissue discrimination algorithm.
Three eyes without marked anterior disorder and an eye with narrow angle were examined by anterior segment PS-OCT. PS-OCT is capable of measuring a full polarization property, so called Jones matrix, of the anterior eye. In the subsequent signal processing, OCT intensity (I), sample birefringence (BR), and light extinction coefficient (EC) were calculated from the Jones matrix for each pixel in the image. For the tissue identification, reference regions of 5 target tissue types (conjunctiva, sclera, cornea, uvea, and trabecular meshwork (TM)) were manually selected. The similarities of each pixel in the tomography to the target tissues were examined by a nearest neighbor rule based on the 3 properties of I, BR, and EC, and the pixels were classified to one of the tissue types.
For all of 4 eyes, 5 target tissues were discriminated. Two 3-dimensional volumes of tissue contrast OCT were created for one normal and one narrow angle eye. In the volumetric OCTs, TM lines were observed as were observed by gonioscopic examination (shown in figure).
Since PS-OCT is a non-contact method, this pseudo-gonioscopic examination would be useful for large scale screening as well as for patients soon after surgeries.
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