April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Tissue Contrast Imaging of Anterior Eye Based on Optical Properties Measured by Polarization Sensitive Optical Coherence Tomography
Author Affiliations & Notes
  • A. Miyazawa
    Computational Optics Group, Univertisy of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • M. Yamanari
    Computational Optics Group, Univertisy of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • S. Makita
    Computational Optics Group, Univertisy of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • M. Miura
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
    Dept of Ophthalmology, Tokyo Medical Univ, Tokyo, Japan
  • K. Kawana
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
    Dept of Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • K. Iwaya
    Dept of Phathology, National Defense Medical College, Saitama, Japan
  • H. Goto
    Dept of Ophthalmology, Tokyo Medical Univ, Tokyo, Japan
  • T. Oshika
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
    Dept of Ophthalmology, University of Tsukuba, Tsukuba, Japan
  • Y. Yasuno
    Computational Optics Group, Univertisy of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Footnotes
    Commercial Relationships  A. Miyazawa, Tomey.corp, F; M. Yamanari, Tomey.corp, F; Tomey.corp, P; S. Makita, Tomey.corp, F; Tomey.corp, P; M. Miura, None; K. Kawana, None; K. Iwaya, None; H. Goto, None; T. Oshika, None; Y. Yasuno, Tomey.corp, F; Tomey.corp, P.
  • Footnotes
    Support  Grant Program of Japan Science Technology Agency
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3853. doi:
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    • Get Citation

      A. Miyazawa, M. Yamanari, S. Makita, M. Miura, K. Kawana, K. Iwaya, H. Goto, T. Oshika, Y. Yasuno; Tissue Contrast Imaging of Anterior Eye Based on Optical Properties Measured by Polarization Sensitive Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3853.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Although tissues of anterior eye have distinctive properties, they are not clearly contrasted by optical coherence tomography (OCT). We employed polarization sensitive OCT (PS-OCT), which measures biefringence of a sample, to discriminate the tissues. This paper aims at demonstrating tissue contrast tomographic imaging of anterior angle by using our newly developed PS-OCT and associate tissue discrimination algorithm.

 
Methods:
 

Three eyes without marked anterior disorder and an eye with narrow angle were examined by anterior segment PS-OCT. PS-OCT is capable of measuring a full polarization property, so called Jones matrix, of the anterior eye. In the subsequent signal processing, OCT intensity (I), sample birefringence (BR), and light extinction coefficient (EC) were calculated from the Jones matrix for each pixel in the image. For the tissue identification, reference regions of 5 target tissue types (conjunctiva, sclera, cornea, uvea, and trabecular meshwork (TM)) were manually selected. The similarities of each pixel in the tomography to the target tissues were examined by a nearest neighbor rule based on the 3 properties of I, BR, and EC, and the pixels were classified to one of the tissue types.

 
Results:
 

For all of 4 eyes, 5 target tissues were discriminated. Two 3-dimensional volumes of tissue contrast OCT were created for one normal and one narrow angle eye. In the volumetric OCTs, TM lines were observed as were observed by gonioscopic examination (shown in figure).

 
Conclusions:
 

Since PS-OCT is a non-contact method, this pseudo-gonioscopic examination would be useful for large scale screening as well as for patients soon after surgeries.  

 
Keywords: anterior segment • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • image processing 
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