April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Ultra-High Resolution Optical Coherence Tomography of the Ageing Lamina Cribrosa
Author Affiliations & Notes
  • R. V. North
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • K. E. Mortlock
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • B. Hermann
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • A. R. Tumlinson
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • B. Povazay
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • J. E. Morgan
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • W. Drexler
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Centre of Biomedical Engineering and Physics, Vienna University of Medicine, Vienna, Austria
  • J. Albon
    School of Optometry & Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • Footnotes
    Commercial Relationships  R.V. North, None; K.E. Mortlock, None; B. Hermann, None; A.R. Tumlinson, None; B. Povazay, None; J.E. Morgan, None; W. Drexler, Carl Zeiss Meditec, C; J. Albon, None.
  • Footnotes
    Support  UK & Eire Glaucoma Society, IGA (UK)
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3856. doi:
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      R. V. North, K. E. Mortlock, B. Hermann, A. R. Tumlinson, B. Povazay, J. E. Morgan, W. Drexler, J. Albon; Ultra-High Resolution Optical Coherence Tomography of the Ageing Lamina Cribrosa. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3856.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the ability of 1050 nm ultra high resolution Fourier-domain (FD) OCT to image all levels of the human lamina cribrosa (LC) for the quantification of parameters associated with normal ageing.

Methods: : OCT image datasets of 36 healthy control subjects (Caucasian individuals, refractive between +1.00D and -4.00D) aged 18-80 years were acquired using two systems operating at separate wavelengths of 800 nm (Cirrus prototype) and 1050 nm (custom device). All subjects underwent contact tonometry (OBF tonometer), visual field examination (24-2 SITA Standard, Humphrey Field Analyser), axial length measurement, scanning laser ophthalmoscopy (Heidelberg Retinal Tomograph II), stereoscopic fundus photography (Nidek 3Dx) and FD-OCT. 1050nm OCT images were processed in MatLab and post-processed using ImageJ (NIH) to correct for eye movements, improve image contrast and reduce noise. Measurements of the retinal nerve fiber layer, prelamina and LC thickness and displacement of the surfaces of the prelamina, anterior and posterior LC relative to Bruch's membrane opening (BMO) were quantified using Image J, Matlab and custom manual segmentation techniques.

Results: : Optic nerve head images acquired using OCT at 1050nm demonstrated excellent depiction of the pores throughout the LC, with clearer definition of pores transversely compared to OCT at 800nm, which appeared to decrease in size with increasing depth into the LC. OCT at 1050nm enabled greater axial penetration allowing visualisation of the deeper ONH tissues, compared to OCT at 800nm allowing full thickness measurements of human LC as a function of age to be determined. The central thickness of LC, measured from the first beams/pores to disappearance of pores or signal, ranged from 266-638 microns with a mean of 423 microns. LC thickness increased with age by 16.7 microns per decade. Central prelamina thickness, measured from the base of the cup to anterior LC, ranged from 40-286 microns with a mean of 167 microns and an age-related decrease of 11.7 microns per decade. No apparent change in displacement (relative to the BMO reference plane) of prelamina and LC surfaces was observed with age.

Conclusions: : OCT at 1050nm provides enhanced visualisation of the LC in vivo. Thickness measures were consistent with previously published ex vivo data in the human LC.

Keywords: lamina cribrosa • aging • imaging/image analysis: clinical 
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