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A. C. Walsh, R. C. Wildey, C. Lara, Y. Ouyang, S. R. Sadda; Detection of Fundus Abnormalities Using 3D-OCT versus Mydriatic Color Fundus Imaging. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3863.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the sensitivity of detection for retinal abnormalitiesusing 3D-OCT versus single field fundus imaging.
Images from consecutive patients in a retina clinic undergoingsimultaneous 3D-OCT (512x128) and single, foveal mydriatic 45degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo,Japan) in an 8 week period were retrospectively collected. Findingsfor each modality (Table 1) were graded independently by twograders (ACW, RCW) as present, questionable or absent. Findingswere separated into 3 categories for intermodality comparisons:epiretinal, retinal/subretinal, and RPE/choroidal. The approximatelocation of findings in relation to the 3D-OCT field was notedas IF for "in field" and OF for "out of field." Findings fromboth modalities were combined to form the gold standard forcomparison for each modality.
501 3D-OCT scans and fundus images of 277 visits of 223 patientswere included in this study. 99% of the scans had abnormal findings.35 fundus images (7%) and 2 3D-OCT scans (<1%) were ungradable.3D-OCT identified some abnormality in 33/35 (94%) of the ungradablefundus images. Detection sensitivities (Table 2) for definiteabnormalities using 3D-OCT were superior or equal to both IFand IF+OF fundus imaging sensitivities in all cases.
In this study, 3D-OCT was superior to fundus imaging in detectingretinal abnormalities in a high disease prevalence population.The rate of ungradable images by 3D-OCT was lower than mydriaticfundus imaging and 3D-OCT detected a high rate of abnormalitiesin patients with ungradable fundus images.
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