April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
En Face Visualization and Quantification of Photoreceptor Inner/ Outer Segment Junction Using Cirrus Spectral Domain Optical Coherence Tomography and Association With Visual Acuity
Author Affiliations & Notes
  • D. F. Kiernan
    Ophthalmology, University of Illinois at Chicago, Chicago, Illinois
  • R. U. Zelkha
    Ophthalmology, University of Illinois at Chicago, Chicago, Illinois
  • J. I. Lim
    Ophthalmology, University of Illinois at Chicago, Chicago, Illinois
  • S. M. Hariprasad
    Ophthalmology, University of Chicago, Chicago, Illinois
  • W. F. Mieler
    Ophthalmology, University of Illinois at Chicago, Chicago, Illinois
  • Footnotes
    Commercial Relationships  D.F. Kiernan, None; R.U. Zelkha, None; J.I. Lim, None; S.M. Hariprasad, None; W.F. Mieler, None.
  • Footnotes
    Support  Core Grant NEI EY014275, Research to Prevent Blindness and the Gerhard Cless Retina Research Fund
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3864. doi:
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      D. F. Kiernan, R. U. Zelkha, J. I. Lim, S. M. Hariprasad, W. F. Mieler; En Face Visualization and Quantification of Photoreceptor Inner/ Outer Segment Junction Using Cirrus Spectral Domain Optical Coherence Tomography and Association With Visual Acuity. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3864.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To describe a novel method of en face visualization of the photoreceptor inner segment/ outer segment junction (IS/OS) using spectral domain Cirrus optical coherence tomography (SD OCT), quantification of the central macular IS/OS area and its association with visual acuity.

 
Methods:
 

Case control study of fifty eyes of 44 patients using Cirrus SD OCT en face visualization and IS/OS-RPE slice mode. The central 1 mm and 400 um IS/OS foveal zones were analyzed with Metamorph computer software, set to the same threshold value for all images.

 
Results:
 

Twenty-five eyes (23 patients) had retinal disease (group 1) with mean logMAR visual acuity (VA) = 0.235, whereas twenty-five eyes (21 patients) served as healthy, age-matched controls with mean VA= 0.081. In group 1, mean central 1 mm and 400 um zone IS/OS areas were 59.2% (+/- 12.7%) and 56.7% (+/-14.7%), which correlated significantly greater with VA (absolute Pearson coefficient= 0.56 and 0.62) than did mean central subfoveal thickness, macular volume or average macular thickness (= 0.16, 0.22, 0.05.) In the control group, mean central 1 mm and 400 um zone IS/OS areas were 76.1% (+/- 13.9%) and 69.8% (+/-13.1%), which correlated significantly greater with VA (= 0.63 and 0.64) than did other macular thickness measurements (= 0.12, 0.06, 0.05.) There was no significant difference between the two IS/OS zone measurements in each group (p>0.05). 68% of group 1 and 52% of controls had cataracts. Figure 1 demonstrates an example of group 1 and control images, central zone measurements and corresponding VA.

 
Conclusions:
 

Central IS/OS area measurement correlates with VA in both healthy eyes and those with retinal disease. It may be a better predictor of VA than other routine SD OCT values, including central subfoveal thickness. The presence of cataract may affect this correlation, and it should be used with caution in patients with significant media opacity. Advancements in SD OCT software may allow for routine en face IS/OS visualization and analysis.  

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • photoreceptors: visual performance • image processing 
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