Purchase this article with an account.
G. Tam, F. Segev, Y. Paitan, E. Assia; Evaluation of Intracorneal Injection of 5% Natamycin for the Treatment of Fusarium Keratitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3905.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare the efficacy of intrastromal injection of Natamycin combined with topical Natamycin to a standard therapy (topical Natamycin) in a rabbit model of Fusarium keratitis.
Fungal keratitis was induced in the right eyes of 12 NZ rabbits by intrastromal injection of Fusarium suspension into the cornea. Rabbits were randomly divided into 2 groups. Group 1 received intrastromal injection of Natamycin on treatment day 1 and 4 combined with topical Natamycin given hourly for 2 days followed by 4 times daily. Group 2 received topical Natamycin at identical interval. The eyes were examined on treatment days 1, 4, 7 and 11. The extent of keratitis was graded by the following parameters: size of infiltrate and epithelial defect, corneal clouding, vascularization and hypopion. At study termination the corneas were examined histopathologically.
Keratitis developed in all eyes. In both groups clinical improvement of keratitis was recorded. Infiltration size was statistically smaller in group 1 (P=0.023). No differences were found as for conjuctival hyperemia, corneal clouding and hypopion. No adverse reactions were found as for the intrastromal drug delivery.
Intrastromal injection of Natamycin combined with topical Natamycin is an effective treatment for Fusarium keratitis.
This PDF is available to Subscribers Only