April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Evaluation of Intracorneal Injection of 5% Natamycin for the Treatment of Fusarium Keratitis
Author Affiliations & Notes
  • G. Tam
    Ophthalmology,
    Meir Medical center, Kefar Sava, Israel
  • F. Segev
    Ophthalmology,
    Meir Medical center, Kefar Sava, Israel
  • Y. Paitan
    Microbiology,
    Meir Medical center, Kefar Sava, Israel
  • E. Assia
    Ophthalmology,
    Meir Medical center, Kefar Sava, Israel
  • Footnotes
    Commercial Relationships  G. Tam, None; F. Segev, None; Y. Paitan, None; E. Assia, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3905. doi:
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      G. Tam, F. Segev, Y. Paitan, E. Assia; Evaluation of Intracorneal Injection of 5% Natamycin for the Treatment of Fusarium Keratitis. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3905.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the efficacy of intrastromal injection of Natamycin combined with topical Natamycin to a standard therapy (topical Natamycin) in a rabbit model of Fusarium keratitis.

Methods: : Fungal keratitis was induced in the right eyes of 12 NZ rabbits by intrastromal injection of Fusarium suspension into the cornea. Rabbits were randomly divided into 2 groups. Group 1 received intrastromal injection of Natamycin on treatment day 1 and 4 combined with topical Natamycin given hourly for 2 days followed by 4 times daily. Group 2 received topical Natamycin at identical interval. The eyes were examined on treatment days 1, 4, 7 and 11. The extent of keratitis was graded by the following parameters: size of infiltrate and epithelial defect, corneal clouding, vascularization and hypopion. At study termination the corneas were examined histopathologically.

Results: : Keratitis developed in all eyes. In both groups clinical improvement of keratitis was recorded. Infiltration size was statistically smaller in group 1 (P=0.023). No differences were found as for conjuctival hyperemia, corneal clouding and hypopion. No adverse reactions were found as for the intrastromal drug delivery.

Conclusions: : Intrastromal injection of Natamycin combined with topical Natamycin is an effective treatment for Fusarium keratitis.

Keywords: keratitis • fungal disease • cornea: stroma and keratocytes 
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