Abstract
Purpose: :
To describe the distribution of central corneal thickness (CCT), intraocular pressure (IOP) and their determinants in elderly Chinese.
Methods: :
CCT was measured using both optical and A-mode ultrasound pachymetry. IOP was measured with Tonopen. Refraction error (RE) and corneal curvature radius (CR) were measured by an autorefractor. Axial length (AL) was obtained by the same A-scan with a biometric probe. History of systemic hypertension (HTN) and diabetes (DM) was collected by a standard questionnaire. Body mass index (BMI) was calculated as weight divided by square of the height. Data were presented for the right eyes.
Results: :
Among 1405 participants in the study, 1185 right eyes were available for the analysis. The mean values of optical corneal thickness (OCCT), ultrasound corneal thickness (UCCT) and IOP were 512.0±28.5 µm, 541.8±30.7 µm and 15.2±2.9 mmHg, respectively. In the multiple regression models, CCT decreased with age (β=-0.44, P<0.001) and increased in people with greater CR (β=14.08, P<0.001) and DM (β=7.58, P=0.049). IOP was positively associated with CCT (β=0.02, P<0.001), BMI (β=0.14, P<0.001) and HTN (β=0.68, P=0.002).
Conclusions: :
The distribution of CCT and IOP in this study is similar with the majority of East Asian populations when the method of measurement is taken into consideration.
Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • intraocular pressure • cornea: clinical science