April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Differences in Primary Open-Angle Glaucoma Subtypes in Filipino- and Caucasian-Americans: A Retrospective Study of Two Clinic Populations
Author Affiliations & Notes
  • S. C. Lin
    Ophthalmology, Univ of California - SF, San Francisco, California
  • C. S. Sáles
    Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts
  • R. Y. Lee
    Ophthalmology, Univ of California - SF, San Francisco, California
  • A. K. Agadzi
    Ophthalmology, Univ of California - SF, San Francisco, California
  • M. R. Hee
    Ophthalmology, Univ of California - SF, San Francisco, California
  • Footnotes
    Commercial Relationships  S.C. Lin, None; C.S. Sáles, None; R.Y. Lee, None; A.K. Agadzi, None; M.R. Hee, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 3988. doi:
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    • Get Citation

      S. C. Lin, C. S. Sáles, R. Y. Lee, A. K. Agadzi, M. R. Hee; Differences in Primary Open-Angle Glaucoma Subtypes in Filipino- and Caucasian-Americans: A Retrospective Study of Two Clinic Populations. Invest. Ophthalmol. Vis. Sci. 2010;51(13):3988.

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Abstract

Purpose: : To compare primary open-angle glaucoma (POAG) subtypes between Filipino- and Caucasian-Americans in a general ophthalmology clinic population.

Methods: : A retrospective cross-sectional epidemiologic study was conducted. Medical charts of 1112 patients aged 40 years or older (500 Filipino, 612 Caucasian) seen in 2008 were randomly sampled from two private comprehensive ophthalmology clinics. Glaucoma was diagnosed based on optic nerve appearance, visual field defects, and other ocular findings according to the International Society of Geographical and Epidemiological Ophthalmology (ISGEO) scheme. The normal-tension subtype (NTG) of POAG was defined by intraocular pressure ≤ 21 mmHg based on review of the entire chart history.

Results: : Filipinos had a higher overall proportion of glaucoma and POAG than Caucasians (Filipino [F] vs. Caucasian [C]: glaucoma, 14.7% vs. 9.3%; POAG, 11.9% vs. 8.2%; P=0.01, P=0.04, respectively). Filipinos had a higher overall proportion of NTG (F vs. C: 6.8% vs. 2.5%; P=0.001), and NTG comprised a greater proportion of all glaucoma in Filipinos (F vs. C: 46.7% vs. 26.8%; P=0.02). Filipinos’ higher proportion of NTG was significant in both clinics (F vs. C: clinic A, 4.0% vs. 0.7%; clinic B, 9.6% vs. 4.1%; P=0.01, P=0.01, respectively), but Filipinos’ higher proportions of glaucoma and POAG were only significant or borderline significant in clinic B (P=0.02, P=0.07, respectively). Filipinos and Caucasians with NTG had comparable central corneal thickness in the cohort and in both clinics (all P>0.05). Filipinos’ higher overall proportion of NTG remained significant after controlling for age and sex (P=0.001).

Conclusions: : There are few or no data describing the characteristics of glaucoma among Filipinos. Results from this retrospective study of two convenience samples suggest that Filipino-Americans may be at higher risk than their Caucasian counterparts for NTG, but this postulate must be confirmed by prospective studies.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • clinical (human) or epidemiologic studies: risk factor assessment 
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