April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Glaucoma Progression After Initial Optic Disc Hemorrhage by Optical Coherence Tomography
Author Affiliations & Notes
  • M. Suh
    Ophthalmology, Seoul National Univ Hospital, Seoul, Republic of Korea
  • K. Park
    Ophthalmology, Seoul National Univ Hospital, Seoul, Republic of Korea
  • H. Kim
    Applied Statistics, Yonsei University, Seoul, Republic of Korea
  • T.-W. Kim
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • S.-Y. Kim
    Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington
  • D. Kim
    Ophthalmology, Seoul National Univ Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  M. Suh, None; K. Park, None; H. Kim, None; T.-W. Kim, None; S.-Y. Kim, None; D. Kim, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4004. doi:https://doi.org/
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      M. Suh, K. Park, H. Kim, T.-W. Kim, S.-Y. Kim, D. Kim; Glaucoma Progression After Initial Optic Disc Hemorrhage by Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4004. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate glaucoma progression after an initial disc hemorrhage (DH) by optical coherence tomography (StratusOCT: Carl Zeiss Meditec, Inc., Dublin, CA).

Methods: : Forty four eyes with a unilateral DH were allocated to the DH group and the 44 contralateral eyes to the non-DH group. Thinning of the retinal nerve fiber layer (RNFL) by OCT was defined as a decrease beyond the upper 95 % limit of test-retest variability defined at the 95 % confidence level of 44 control subjects. The DH and non-DH group were compared in terms of OCT-derived glaucoma progressions after initial DH. In addition, clock hour locations of OCT-derived progression were compared with those of DHs.

Results: : After a median 38.8 months of follow-up, 72.7 % (32/44) of eyes in the DH group showed OCT-determined clock hour thickness progression, as compared with 27.3 % (12/44) in the non-DH group (P < 0.0001, Fisher’s exact test). The DH-group showed more rapid and greater falls in clock hour thickness progression than the non-DH group (P < 0.0001, log rank test). Twenty nine eyes (90.6 %) showed progression within 1 clock hour of the location of DH. However, no significant inter-group differences were observed in terms of quadrant or average RNFL thicknesses (P > 0.05, respectively, Fisher’s exact test).

Conclusions: : Rapid, spatially-compatible, localized thinning of the RNFL after initial DH was detected by StratusOCT. This finding suggests DH is not a simple epiphenomenon of structural damage, but that it may also lead to subsequent RNFL thinning.

Keywords: optic disc 
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