April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Laser Activated Gold Nanoparticles for the Welding of Ocular Tissues
Author Affiliations & Notes
  • L. Menabuoni
    U O Oculistica, Azienda USL 4 Prato, Prato, Italy
  • I. Lenzetti
    Azienda USL 4 Prato, U O Oculistica, Prato, Italy
  • L. Cortesini
    Azienda USL 4 Prato, U O Oculistica, Prato, Italy
  • F. Rossi
    IFAC, CNR, Sesto Fiorentino (FI), Italy
  • F. Ratto
    IFAC, CNR, Sesto Fiorentino (FI), Italy
  • R. Pini
    IFAC, CNR, Sesto Fiorentino (FI), Italy
  • Footnotes
    Commercial Relationships  L. Menabuoni, None; I. Lenzetti, None; L. Cortesini, None; F. Rossi, None; F. Ratto, None; R. Pini, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4219. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      L. Menabuoni, I. Lenzetti, L. Cortesini, F. Rossi, F. Ratto, R. Pini; Laser Activated Gold Nanoparticles for the Welding of Ocular Tissues. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4219.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To demonstrate the suitability of gold nanorods as chromophores to mediate the infrared laser welding of ocular tissues

Methods: : Gold nanorods, with an optical absorption at 800 nm, have been synthesised to be used as laser chromophores in diode laser welding procedures. Porcine anterior capsular and corneal tissues were used. A patch of both tissues was stained with the nanorods and then laid onto the same intact tissue. Irradiation was performed with diode laser. The welded tissue sandwiches were then prepared for histological examination.

Results: : Successful and reproducible welding was achieved with satisfactory mechanical strength of the weld. Histological analysis showed thermal denaturation and soldering of the endogenous collagen all through the weld sites.

Conclusions: : Gold nanorods are suitable exogenous chromophores for the laser welding of ocular tissues. They can be potentially used to perform the closure of capsulorhexes in lens refilling procedures, offering high stability and functionalization to target specific connective tissues.

Keywords: laser • cornea: basic science 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.