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L. Ibares-Frias, P. Gallego, M. C. Martinez, R. Cantalapiedra, P. Pérez-Merino, S. del Olmo, I. Alcalde, T. Blanco, J. Merayo-Lloves; Clinical and Histological Reversibility of Intrastromal Corneal Ring Segments. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4223.
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To evaluate the outcome and potencial reversibility of the clinical and histological changes induced in the corneas of an animal model after intra stromal ring segment explantation.
We performed surgery for this study in 12 eyes (6hens), in an experimental animal model (Gallus Domesticus ) of intra stromal ring-segment implantation (Ferrara technique) previously described by us.The animals were randomized in 3 groups ,in all of them, we implanted one segment in each eye and was removed in 3 months .Each Group was processed in differents time points, ,at 12 hours (first Group), 7 days (second Group) and 15 days, (third Group) for histological Analysis.
Explantation was performed easily in all cases without intraoperative or postoperative complications.Clinical results: we observed a moderate degree of corneal opacity in the first hours which decrease later.Histological results: 12 hours after removing the ring , we observed hipercelularity and collagen fibres located around the empty space left by the segment, after 15 days collagen fibres are similar to preoperatory conformation, with persistence of the same hipercelularity.
Preliminary data from this study indicate that removal of segments resulted in reversal of thehistological and clinical changes induced by the segment implantation
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