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Y. Okamoto, F. Okamoto, T. Hiraoka, T. Oshika; Retinal Nerve Fiber Layer Thickness Following Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4231.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the influence of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) on retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT).
Twenty five eyes of 25 patients (33 to 73 years old) undergoing primary PPV for PDR were studied. RNFLT was evaluated using OCT (Stratus OCT 3000, Carl Zeiss) before, 2, 4, 12, and 24 weeks after PPV. Superior, inferior, nasal, temporal, and average RNFLT were analyzed. Multivariate analysis was performed to investigate the relationship between various explanatory factors and average RNFLT. Explanatory factors included age, severity of PDR, number of laser photocoagulation, operation time, use of gas tamponade, and highest intraocular pressure after surgery.
Average RNFLT tended to decrease after PPV throughout the follow-up period. Average RNFLT at 6 months after PPV was significantly thinner than that at 2 and 4 weeks postoperatively (p<0.05). Multivariate analysis revealed that operation time was significantly associated with average RNFLT at 6 months after PPV (p<0.05).
RNFLT progressively decreased with time after PPV for PDR. Longer operation time was found to be significantly relevant with the postoperative thinning of RNFLT.
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