April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Retinal Nerve Fiber Layer Thickness Following Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy
Y. Okamoto; F. Okamoto; T. Hiraoka; T. Oshika
Author Affiliations & Notes
  • Y. Okamoto
    Dept of Ophthalmology, Institute of Clin, University of Tsukuba, Tsukuba, Japan
  • F. Okamoto
    Dept of Ophthalmology, Institute of Clin, University of Tsukuba, Tsukuba, Japan
  • T. Hiraoka
    Dept of Ophthalmology, Institute of Clin, University of Tsukuba, Tsukuba, Japan
  • T. Oshika
    Dept of Ophthalmology, Institute of Clin, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships  Y. Okamoto, None; F. Okamoto, None; T. Hiraoka, None; T. Oshika, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4231. doi:
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      Y. Okamoto, F. Okamoto, T. Hiraoka, T. Oshika; Retinal Nerve Fiber Layer Thickness Following Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4231.

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Abstract

Purpose: : To assess the influence of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) on retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT).

Methods: : Twenty five eyes of 25 patients (33 to 73 years old) undergoing primary PPV for PDR were studied. RNFLT was evaluated using OCT (Stratus OCT 3000, Carl Zeiss) before, 2, 4, 12, and 24 weeks after PPV. Superior, inferior, nasal, temporal, and average RNFLT were analyzed. Multivariate analysis was performed to investigate the relationship between various explanatory factors and average RNFLT. Explanatory factors included age, severity of PDR, number of laser photocoagulation, operation time, use of gas tamponade, and highest intraocular pressure after surgery.

Results: : Average RNFLT tended to decrease after PPV throughout the follow-up period. Average RNFLT at 6 months after PPV was significantly thinner than that at 2 and 4 weeks postoperatively (p<0.05). Multivariate analysis revealed that operation time was significantly associated with average RNFLT at 6 months after PPV (p<0.05).

Conclusions: : RNFLT progressively decreased with time after PPV for PDR. Longer operation time was found to be significantly relevant with the postoperative thinning of RNFLT.

Keywords: diabetic retinopathy • vitreoretinal surgery 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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