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R. V. Vemala, S. Koshy, S. B. Jyothi; Qualitative and Quantitative OCT Changes Following Laser Photocoagulation for Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4251.
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The purpose of this study is to assess the morphological and quantitative changes of the macula in response to macular laser for clinically significant diabetic macular edema (CSME).
Cirrus OCT scans of 30 eyes of 25 patients were retrospectively analysed before and 4 months after macular laser for CSME. The edema was quantified and response evaluated in the 9 ETDRS zones of the macula. Post-laser OCT changes were correlated to the baseline features including number of parafoveal quadrants involved, the layers of the retina involved, visual acuity and Hb1AC.
The region of the grid with the best response to laser was the central zone (decrease in mean 29.67 microns).The region with the worst response to laser was the inner superior zone (decrease in mean 1.41 microns).The edema responded best when it involved both the inner and outer layers of retina (decrease in mean 21.16 microns), the worst response was when it involved only the outer layer (decrease in mean 6.7 microns). The edema responded best when it involved 4 or less quadrants ( decrease in mean 8.69 microns) than when it involved 4 or more quadrants(decrease in mean 0.2 microns).
The location of edema and the morphological pattern of the edema on OCT are useful predictors of treatment response in CSME.
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