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C. A. Johnson, M. Wall, C. K. Doyle, C. Brito, K. Sherman, K. Woodward; A Continuous Probability Scale for Size III, Size V, Motion and Matrix Perimetry. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4333.
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© ARVO (1962-2015); The Authors (2016-present)
To apply a continuous probability scale to Size III, Size V, Motion and Humphrey Matrix Frequency Doubling Technology Perimetry and compare their results in glaucoma patients.
Age adjusted empiric continuous probability plots were determined for each test procedure based upon data obtained from both eyes of the same 60 normal control subjects (ages 40-78), using test patterns similar to a 24-2 stimulus configuration. These evaluations were then applied to eyes from 120 glaucoma patients with varying degrees of damage (Size III MD = -6.67 ave, 4.4 s.d.).
At the 1%, 2% and 5% probability levels, normal and abnormal values were similar for Size III and V, but both Size III and V were different from Motion and Matrix while Matrix had the fewest normal locations. The table below presents the increase in percentage of abnormal points at the 10, 15 and 20% levels for the four tests in comparison to the expected normal increases. The size III results were slightly below expected normal values, while Size V, Motion and Matrix yielded higher than expected increases in abnormal values at the 10, 15 and 20% levels.
Size V, Motion and Matrix Perimetry reveal a greater proportion of points below the 20, 15 and 10 % normal levels in glaucoma patients than size III. This suggests a better clinical combination of higher sensitivity and lower variability. Continuous probability scales may be useful in detecting early glaucomatous visual field losses and progressive visual field changes.
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