April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Fourier Domain Optical Coherence Tomography Blood Flow Assessment in Patients With Glaucoma: A New Blood Flow Method
Author Affiliations & Notes
  • A. Harris
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • O. Tan
    Ophthalmology, USC, Keck School of Medicine, Doheny Eye Institute, Los Angeles, California
  • B. Siesky
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • Y. Shoshani
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • R. Pappuru
    Ophthalmology, USC, Keck School of Medicine, Doheny Eye Institute, Los Angeles, California
  • R. Ehrlich
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • S. R. Sadda
    Ophthalmology, USC, Keck School of Medicine, Doheny Eye Institute, Los Angeles, California
  • D. Rusia
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • A. Moss
    Ophthalmology, Indiana Univ Sch of Medicine, Indianapolis, Indiana
  • D. Huang
    Ophthalmology, USC, Keck School of Medicine, Doheny Eye Institute, Los Angeles, California
  • Footnotes
    Commercial Relationships  A. Harris, Pfizer pharmaceuticals, C; O. Tan, Optovue Inc., F; B. Siesky, None; Y. Shoshani, None; R. Pappuru, None; R. Ehrlich, None; S.R. Sadda, Optovue Inc., Carl Zeiss Meditec, F; Heidelberg Engineering, Allergan, Genentech, C; Topcon Medical Systems, P; Topcon Medical Systems, R; D. Rusia, None; A. Moss, None; D. Huang, Optovue Inc., F; Optovue Inc., I; Optovue Inc., C; Carl Zeiss Meditec inc, P; Optovue Inc., R.
  • Footnotes
    Support  Pfizer pharmaceuticals, NIH R01 EY013516 and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4336. doi:
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      A. Harris, O. Tan, B. Siesky, Y. Shoshani, R. Pappuru, R. Ehrlich, S. R. Sadda, D. Rusia, A. Moss, D. Huang; Fourier Domain Optical Coherence Tomography Blood Flow Assessment in Patients With Glaucoma: A New Blood Flow Method. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4336.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine Fourier domain optical coherence tomography (OCT) blood flow in patients with open angle glaucoma (OAG) participating in the Indianapolis Glaucoma Progression Study (IGPS) and healthy controls and explore its relationships with retrobulbar blood flow and retinal capillary microcirculation.

Methods: : Fourier domain OCT assessment of total retinal blood flow, color Doppler imaging (CDI) of retrobulbar blood vessels and confocal scanning laser Doppler flowmetry (Heidelberg Retinal Flowmeter; HRF) of retinal microcirculation were conducted in five patients with OAG (mean age 55.6; 4 male) participating in the IGPS. Five healthy controls (25.6; 5 male) were also examined at the same time for Fourier domain OCT blood flow. CDI measures of retrobulbar blood flow velocities [peak systolic and end diastolic blood flow velocities (PSV/EDV)] and Pourcelot’s vascular resistance index (RI) were calculated in the ophthalmic, central retinal, and nasal and temporal short posterior ciliary arteries. HRF measures of mean retinal capillary blood flow and the percentage of zero blood flow pixels were determined. Student’s t tests were used to determine differences in Fourier domain OCT total retinal blood flow between patients with OAG and healthy controls. Pearson correlation analysis examined the relationship between Fourier domain OCT retinal blood flow, retrobulbar blood flow and retinal capillary microcirculation in patients with OAG. P <0.05 were considered statistically significant.

Results: : Patients with OAG had significantly lower (23.9%) total retinal blood flow compared to healthy controls (38.1 ul/min; 47.2 ul/min, p=0.001). In the OAG cohort, there was a statistically significant correlation between ophthalmic artery PSV and nasal short posterior ciliary arteries EDV and OCT Doppler blood flow (r=0.91, p=0.03; r=0.89, p=0.04), respectfully. Central retinal artery PSV (r=0.77) and EDV (r=0.79) both had strong (non-significant) positive correlations to total retinal blood flow. There was no statistically significant (p>0.05) correlation between retinal capillary blood flow measured by HRF and Doppler OCT total retinal blood flow.

Conclusions: : In this pilot study, we report patients with OAG have lower total retinal blood flow than healthy controls measured with Fourier domain OCT. Total retinal blood flow is correlated with blood flow velocities in the retrobulbar blood vessels measured with CDI.

Keywords: imaging/image analysis: clinical • blood supply • clinical (human) or epidemiologic studies: systems/equipment/techniques 
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