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A. Harris, O. Tan, B. Siesky, Y. Shoshani, R. Pappuru, R. Ehrlich, S. R. Sadda, D. Rusia, A. Moss, D. Huang; Fourier Domain Optical Coherence Tomography Blood Flow Assessment in Patients With Glaucoma: A New Blood Flow Method. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4336.
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© ARVO (1962-2015); The Authors (2016-present)
To examine Fourier domain optical coherence tomography (OCT) blood flow in patients with open angle glaucoma (OAG) participating in the Indianapolis Glaucoma Progression Study (IGPS) and healthy controls and explore its relationships with retrobulbar blood flow and retinal capillary microcirculation.
Fourier domain OCT assessment of total retinal blood flow, color Doppler imaging (CDI) of retrobulbar blood vessels and confocal scanning laser Doppler flowmetry (Heidelberg Retinal Flowmeter; HRF) of retinal microcirculation were conducted in five patients with OAG (mean age 55.6; 4 male) participating in the IGPS. Five healthy controls (25.6; 5 male) were also examined at the same time for Fourier domain OCT blood flow. CDI measures of retrobulbar blood flow velocities [peak systolic and end diastolic blood flow velocities (PSV/EDV)] and Pourcelot’s vascular resistance index (RI) were calculated in the ophthalmic, central retinal, and nasal and temporal short posterior ciliary arteries. HRF measures of mean retinal capillary blood flow and the percentage of zero blood flow pixels were determined. Student’s t tests were used to determine differences in Fourier domain OCT total retinal blood flow between patients with OAG and healthy controls. Pearson correlation analysis examined the relationship between Fourier domain OCT retinal blood flow, retrobulbar blood flow and retinal capillary microcirculation in patients with OAG. P <0.05 were considered statistically significant.
Patients with OAG had significantly lower (23.9%) total retinal blood flow compared to healthy controls (38.1 ul/min; 47.2 ul/min, p=0.001). In the OAG cohort, there was a statistically significant correlation between ophthalmic artery PSV and nasal short posterior ciliary arteries EDV and OCT Doppler blood flow (r=0.91, p=0.03; r=0.89, p=0.04), respectfully. Central retinal artery PSV (r=0.77) and EDV (r=0.79) both had strong (non-significant) positive correlations to total retinal blood flow. There was no statistically significant (p>0.05) correlation between retinal capillary blood flow measured by HRF and Doppler OCT total retinal blood flow.
In this pilot study, we report patients with OAG have lower total retinal blood flow than healthy controls measured with Fourier domain OCT. Total retinal blood flow is correlated with blood flow velocities in the retrobulbar blood vessels measured with CDI.
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