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R. R. Owsiak, S. N. Martin, K. A. Drenser; Central Foveal Thickness in Children With Bilateral Amblyopia. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4348.
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To compare the central foveal thickness in children with decreased vision to recently published normative data.
Retrospective chart review examining the central foveal thickness (CFT) as measured by optical coherence tomography (OCT) in children ages twelve and younger with bilateral amblyopia, defined as a best corrected visual acuity (BCVA) of ≤ 20/25. Charts were selected by searching the OCT databases for patients age twelve years and younger. These patient’s charts were then reviewed along with the OCT images. Patients were included if (1) bilateral retinal OCT was performed and (2) if BCVA was ≤ 20/25 OU. Patients were excluded if there was evidence of retinal pathology which could account for their decreased BCVA or abnormal retinal thickness due to structural anomalies. Amblyopia was further categorized as mild (20/25-20/40), moderate (20/50-20/100), or severe (<20/100) based on the patient’s better seeing eye. Patient age, BCVA, CFT, and any significant exam findings were recorded in a table. CFT was compared to the pediatric normative value of 221 ±10.9 microns.
The data from twelve eyes of six patients ages six to eleven years old were reviewed. A total of fourteen patients were excluded from our study. Eight had congenital x-linked retinoschisis, three had familial exudative vitreoretinopathy, and three had no recorded BCVA. Of those included in the study, 50% (3/6) had mild and 50% (3/6) had moderate degrees of amblyopia; no patients had severe amblyopia. 33% (4/12) had normal CFT, 33% (4/12) had decreased CFT and 33% (4/12) had increased CFT. 66% (8/12) of eyes had some nonspecific retinal pigment epithelial changes. One patient had high hyperopia with astigmatism; one patient had moderate-high myopia with astigmatism.
At this time there does not appear to be a consistent relationship between bilateral amblyopia and central foveal thickness. However, more data is currently being collected as normative OCT data for the pediatric population has only recently been published. A larger sample size will be necessary to determine if there is a correlation between the variables.
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