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Z. S. Rentiya, E. H. Naimi, S. M. Shah, P. Turkcuoglu, R. Channa, M. A. Ibrahim, A. Khwaja, J. Talmud, D. V. Do, Q. D. Nguyen; Evaluation of time Domain and Spectral Domain Optical Coherence Tomography (OCT) in the Measurement of Macular Edema Secondary to Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4383.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate macular thickness, agreement and intraclass repeatability in three Optical Coherence Tomography (OCT) systems: the time domain (TD) StratusTM OCT, and two spectral domain (SD) OCTs, SpectralisTM and CirrusTM in eyes with retinal vein occlusion (RVO).
Thirty five eyes with Retinal Vein Occlusion (15 (42.86%) eyes with central and 20 (57.14%) with branch vein occlusion) were scanned with all three OCT machines in a single visit by a single operator between March to November 2009. Macular thickness measurements of nine standard subfields were analyzed. Agreement in macular measurements was assessed by constructing Bland-Altman plots. Intraclass repeatability was assessed by Intraclass correlation coefficients (ICCs).
Both Cirrus SD-OCT and Spectralis OCT systems showed a higher mean macular thickness in nine retinal subfields compared to the StratusTM. The difference was significant in some of the nine subfields. Comparison between the two SD OCTs, only the central subfield thickness was significantly higher in Spectralis OCT system than in Cirrus SD-OCT (mean difference of 25.93 µm, 95% Confidence Interval (CI); 10.80, 41.01). In addition, there was no significant difference in 8 peripheral fields between these two systems. Based on the Bland-Altman plots for central macular thickness, there was low agreement between the measurements of Cirrus SD-OCT and Stratus OCT, as well as between Spectralis OCT and Stratus OCT (95% limits of agreement were between -147 and 264 µm for former comparison and between -211 and 386 µm for latter one). The 95% limits of agreement for the same measurement between Cirrus SD-OCT and SpectralisTM OCT ranged from -57 to 18 µm. All three systems demonstrated high intraclass repeatability with ICC of 0.80 (95% CI; 0.64, 0.89) for Cirrus SD-OCT, 0.92 (95% CI; 0.84, 0.96) for Spectralis OCT and 0.97 (95% CI; 0.94, 0.99) for Stratus OCT.
The three OCT imaging systems reported different absolute measures of macular thickness in patients with vein occlusion. Better agreement between Spectral domain systems makes it possible to use them interchangeably. All three systems are reliable in generating macular measurements for clinical practice and research.
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