April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Assessing Reproducibility and Variation Between Time Domain versus Spectral Domain Optical Coherence Tomography in Patients With Diabetic Macular Edema
A. A. Khwaja; E. H. Naimi; R. Channa; M. Ibrahim; M. Shulman; Z. Rentiya; J. Talmud; D. V. Do; Q. D. Nguyen
Author Affiliations & Notes
  • A. A. Khwaja
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • E. H. Naimi
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • R. Channa
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • M. Ibrahim
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • M. Shulman
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Z. Rentiya
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • J. Talmud
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • D. V. Do
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Q. D. Nguyen
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  A.A. Khwaja, None; E.H. Naimi, None; R. Channa, None; M. Ibrahim, None; M. Shulman, None; Z. Rentiya, None; J. Talmud, None; D.V. Do, Heidelberg Inc., F; Q.D. Nguyen, Heidelberg Inc., F.
  • Footnotes
    Support  Mohamed A. Ibrahim is a recipient of a research fellowship from the Egyptian Ministry of Higher Education.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4389. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Assessing Reproducibility and Variation Between Time Domain versus Spectral Domain Optical Coherence Tomography in Patients With Diabetic Macular Edema
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      A. A. Khwaja, E. H. Naimi, R. Channa, M. Ibrahim, M. Shulman, Z. Rentiya, J. Talmud, D. V. Do, Q. D. Nguyen; Assessing Reproducibility and Variation Between Time Domain versus Spectral Domain Optical Coherence Tomography in Patients With Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4389.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To evaluate retinal thickness, agreement in macular thickness measurement and the intra-class reproducibility of images across one time domain (TD) and two spectral domain (SD) optical coherence tomography (OCT) machines, in patients with diabetic macular edema (DME).

Methods: : 61 eyes with DME were scanned with StratusTM (TD), CirrusTM (SD), and SpectralisTM (SD) OCT devices. The same operator performed the scans on all three OCT devices for a given patient. Macular thickness measurements of 9 standard subfields were obtained and analyzed. Agreement in macular thickness across OCT devices was assessed via Bland-Altman (BA) plots. Intra-class reproducibility was evaluated by Intra-class Correlation Coefficient (ICC).

Results: : Scans for Cirrus SD-OCT and Spectralis SD-OCT showed higher macular thickness values in all subfields compared to Stratus TD-OCT. Mean central 1mm foveal thickness in µm (+Standard Deviation) was 282.80 (+99.88), 320.62 (+106.91) and 336.44 (+111.44) for Stratus TM, CirrusTM and SpectralisTM respectively. The BA plots gave a mean difference for the central subfield, in µm (95% Confidence Interval (CI)) of 37.8 (129.3, -53.6), -53.6 (26.8, -134) and -15.8 (47.5, -79.1) for StratusTM vs. CirrusTM, StratusTM vs. SpectralisTM and CirrusTM vs. SpectralisTM, respectively. High intra-class reproducibility was seen among all three systems: StratusTM: ICC of 0.99 (95% CI; 0.97, 0.99); CirrusTM: ICC of 0.98 (95% CI; 0.96, 0.99); SpectralisTM: ICC of 0.99 (95% CI; 0.99, 0.99).

Conclusions: : All three OCT machines showed different macular thickness measurements. Low agreement in macular thickness measurements among machines makes it difficult to use them interchangeably in patients with DME. However, based on the high ICCs, we conclude that there is excellent reproducibility in thickness values and all three OCT machines are reliable in measuring macular thickness in patients with DME.

Keywords: edema • diabetic retinopathy • imaging/image analysis: clinical 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept