Purchase this article with an account.
A. A. Khwaja, E. H. Naimi, R. Channa, M. Ibrahim, M. Shulman, Z. Rentiya, J. Talmud, D. V. Do, Q. D. Nguyen; Assessing Reproducibility and Variation Between Time Domain versus Spectral Domain Optical Coherence Tomography in Patients With Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4389.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate retinal thickness, agreement in macular thickness measurement and the intra-class reproducibility of images across one time domain (TD) and two spectral domain (SD) optical coherence tomography (OCT) machines, in patients with diabetic macular edema (DME).
61 eyes with DME were scanned with StratusTM (TD), CirrusTM (SD), and SpectralisTM (SD) OCT devices. The same operator performed the scans on all three OCT devices for a given patient. Macular thickness measurements of 9 standard subfields were obtained and analyzed. Agreement in macular thickness across OCT devices was assessed via Bland-Altman (BA) plots. Intra-class reproducibility was evaluated by Intra-class Correlation Coefficient (ICC).
Scans for Cirrus SD-OCT and Spectralis SD-OCT showed higher macular thickness values in all subfields compared to Stratus TD-OCT. Mean central 1mm foveal thickness in µm (+Standard Deviation) was 282.80 (+99.88), 320.62 (+106.91) and 336.44 (+111.44) for Stratus TM, CirrusTM and SpectralisTM respectively. The BA plots gave a mean difference for the central subfield, in µm (95% Confidence Interval (CI)) of 37.8 (129.3, -53.6), -53.6 (26.8, -134) and -15.8 (47.5, -79.1) for StratusTM vs. CirrusTM, StratusTM vs. SpectralisTM and CirrusTM vs. SpectralisTM, respectively. High intra-class reproducibility was seen among all three systems: StratusTM: ICC of 0.99 (95% CI; 0.97, 0.99); CirrusTM: ICC of 0.98 (95% CI; 0.96, 0.99); SpectralisTM: ICC of 0.99 (95% CI; 0.99, 0.99).
All three OCT machines showed different macular thickness measurements. Low agreement in macular thickness measurements among machines makes it difficult to use them interchangeably in patients with DME. However, based on the high ICCs, we conclude that there is excellent reproducibility in thickness values and all three OCT machines are reliable in measuring macular thickness in patients with DME.
This PDF is available to Subscribers Only