April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Retinal Nerve Fiber Layer (RNFL) Thickness Measurement Reproducibility Comparison Across Three Spectral Domain Optical Coherence Tomography (SD-OCT) Devices With Systematic Bias Correction
N. M. Buchser; H. Ishikawa; G. Wollstein; R. A. Bilonick; Y. Ling; L. S. Folio; L. Kagemann; R. J. Noecker; E. Albeiruti; J. S. Schuman
Author Affiliations & Notes
  • N. M. Buchser
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • G. Wollstein
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
  • Y. Ling
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • L. S. Folio
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • L. Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • R. J. Noecker
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • E. Albeiruti
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. S. Schuman
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  N.M. Buchser, None; H. Ishikawa, Bioptigen, P; G. Wollstein, Carl Zeiss Meditec; Optovue, F; Bioptigen, P; R.A. Bilonick, None; Y. Ling, None; L.S. Folio, None; L. Kagemann, None; R.J. Noecker, None; E. Albeiruti, None; J.S. Schuman, Carl Zeiss Meditec; Bioptigen, P; Carl Zeiss Meditec; Heidelberg Engineering; Pfizer, R.
  • Footnotes
    Support  NIH R01-EY013178, P30-EY008098; R01-EY013516; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4394. doi:
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      N. M. Buchser, H. Ishikawa, G. Wollstein, R. A. Bilonick, Y. Ling, L. S. Folio, L. Kagemann, R. J. Noecker, E. Albeiruti, J. S. Schuman; Retinal Nerve Fiber Layer (RNFL) Thickness Measurement Reproducibility Comparison Across Three Spectral Domain Optical Coherence Tomography (SD-OCT) Devices With Systematic Bias Correction. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4394.

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Abstract

Purpose: : To compare the RNFL measurement reproducibility across three SD-OCT devices using their native default scan protocol and analysis while correcting for systematic measurement bias.

Methods: : Forty eyes of 20 healthy volunteers underwent peripapillary RNFL thickness measurements using three SD-OCT devices: Cirrus HD-OCT optic nerve head (ONH) cube 200x200 protocol (Carl Zeiss Meditec, Dublin, CA); RTVue ONH protocol (16 radial lines and 8 concentric circles of various diameters, each centered on the ONH; Optovue, Fremont, CA); 3D OCT-1000 3D Scan 256x256 protocol (Topcon, Paramus, NJ) on the same day. All images were qualified for the manufacturer recommended image quality. RNFL measurement reproducibility was assessed by calculating bias and imprecision using a structural equation model. Estimated imprecision after correcting for bias represented measurement reproducibility that was directly comparable across the different devices.

Results: : Global mean RNFL thickness measurement showed estimated imprecision (scale bias corrected) of 2.76 (Cirrus), 7.76 (RTVue), and 4.36 (3D OCT-1000). In other words, RTVue was 2.8x more imprecise and 3D OCT-1000 was 1.6x more imprecise than Cirrus in global RNFL measurement.

Conclusions: : Cirrus RNFL measurement had the best measurement reproducibility among the three tested SD-OCT devices. Three dimensional cube scanning with post-hoc data sampling may be a factor reducing imprecision.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic nerve 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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