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E. Marziani, P. Ramolfo, S. Pomati, P. Contri, M. Suardelli, M. Cigada, C. Mariani, G. Staurenghi; Evaluation of Nerve Fiber Layer and Ganglion Cells Layer Thickness in Parkinson's Disease. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4411.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate differences in Retinal Nerve Fiber Layer (RNFL) thickness and RFNL+ Ganglion Cells Layer (GCL) in patients affected by Parkinson’s Disease (PD), compared to age and sex-matched healthy subjects.
Patients and controls underwent neurological examination, Mini Mental State Examination (MMSE), clock drawing test (CDT) and comprehensive ophthalmic evaluation. Spectral-Domain Optical Coherence Tomography (SD-OCT) examination was performed with Spectralis (Heidelberg Engineering), and RTVue-100 (Optovue Inc). RNFL thickness map was obtained with Spectralis volume protocol with 19 lines on 30° field centered on fovea. On each B-scan the outer RNFL limit was manually set. RFNL+GCL thickness map was obtained with RTVue-100 MM6 protocol. Maps were divided in 9 zones (central, superior internal, temporal internal, inferior internal, nasal internal, superior external, temporal external, inferior external, nasal external) and each map value in every field was evaluated. Exclusion criteria were the presence of any possible cause of RNFL and GCL thickness alteration.
We analyzed 22 PD patients (22 eyes) and 28 healthy subjects (28 eyes) with both RTVue-100 and Spectralis OCT. No significant difference in RNFL+GCL thickness measurements in PD patients was demonstrated in any field (ANOVA: p value between 0.2733 and 0.8634), compared to healthy subjects. RNFL thickness measurements in PD patients are reduced in central and temporal internal fields only (ANOVA: p value respectively 0.0009 and 0.0022), compared to healthy subjects.
The difference between Spectralis and RTVue-100 in the central and temporal internal fields seems suggest that the alteration in these sectors are related only to retinal fiber layer, without involvement of ganglion cells. More studies are necessary to understand the significance of these results.
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