April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Change in Angle Parameters Following Laser Iridotomy in West African Subjects With Primary Angle Closure
Author Affiliations & Notes
  • W. Nolan
    Birmingham and Midland Eye Centre, Birmingham, United Kingdom
  • P. S. Lee
    Institute of Ophthalmology, London, United Kingdom
  • D. L. Budenz
    Ophthal, Epidemiol & Public Hlth, Bascom Palmer Eye Institute, Miami, Florida
  • C. Bunce
    Moorfields Eye Hospital, London, United Kingdom
  • K. Barton
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships  W. Nolan, None; P.S. Lee, None; D.L. Budenz, None; C. Bunce, None; K. Barton, None.
  • Footnotes
    Support  Unrestricted grants from Pfizer global and Allergan Inc. Heidleberg engineering
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4431. doi:
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    • Get Citation

      W. Nolan, P. S. Lee, D. L. Budenz, C. Bunce, K. Barton; Change in Angle Parameters Following Laser Iridotomy in West African Subjects With Primary Angle Closure. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4431.

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      © ARVO (1962-2015); The Authors (2016-present)

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To compare angle width in west african eyes with primary angle closure before and after laser iridotomy using slit-lamp based anterior segment optical coherence tomography (SL-OCT)


Subjects diagnosed with appositional angle closure on gonioscopy during a population-based survey in Ghana were offered treatment with sequential Argon/YAG laser iridotomy. Anterior segment OCT images of the nasal and temporal angles were obtained in dim lighting conditions using the SL-OCT prior to and following iridotomy. The following angle parameters were measured for each angle quadrant using semi-automated software after observer identification of scleral spur on best quality scans: Anterior chamber angle and angle opening distance at 500 microns anterior to scleral spur (ACA500 and AOD500) and trabecular iris space area at 750 microns anterior to scleral spur (TISA750). The measurements for each eye pre and post-iridotomy were compared using paired t-test.


Eighteen right eyes of 18 subjects with angle closure underwent laser iridotomy. There was a significant increase in the angle width as measured by all three parameters for both nasal and temporal angles (see table)


There is significant widening of the angle following iridotomy in West African subjects with primary angle closure when measured with anterior segment imaging. This suggests that pupil block plays a role in the mechanisms of angle closure in this African population.  

Keywords: anterior segment • imaging/image analysis: clinical • laser 

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