April 2010
Volume 51, Issue 13
ARVO Annual Meeting Abstract  |   April 2010
Associations Between Variants in Loc387715, Smoking and Age- Related Macular Degeneration in the Eureye Study
Author Affiliations & Notes
  • A. E. Fletcher
    Epidemiology & Population Health, London Sch of Hygiene & Trop Med, London, United Kingdom
  • U. Chakravarthy
    Ophthalmology, Queens University of Belfast, Belfast, United Kingdom
  • M. Rahu
    Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn, Estonia
  • J. Seland
    Øyeavdelingen, Haukeland Sykehus, University of Bergen, Bergen, Norway
  • R. Sofat
    Clinical Pharmacology, University College London, London, United Kingdom
  • G. Soubrane
    Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • L. Tomazzoli
    Clinica Oculistica, Università degli Studi di Verona, Verona, Italy
  • F. Topouzis
    Ophthalmology, Aristotle Univ of Thessaloniki, Thessaloniki, Greece
  • J. R. Vingerling
    Ophthalmology/Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • J. Vioque
    Dpto. Salud Publica, Universidad Miguel Hernandez, Alicante, Spain
  • Footnotes
    Commercial Relationships  A.E. Fletcher, None; U. Chakravarthy, None; M. Rahu, None; J. Seland, None; R. Sofat, None; G. Soubrane, None; L. Tomazzoli, None; F. Topouzis, None; J.R. Vingerling, None; J. Vioque, None.
  • Footnotes
    Support  European Commission QLK-6-CT-1999-02094, Macular Disease Society, Medical Research Council UK
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4539. doi:
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      A. E. Fletcher, U. Chakravarthy, M. Rahu, J. Seland, R. Sofat, G. Soubrane, L. Tomazzoli, F. Topouzis, J. R. Vingerling, J. Vioque; Associations Between Variants in Loc387715, Smoking and Age- Related Macular Degeneration in the Eureye Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4539.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Previous studies have reported associations between age- related macular degeneration (AMD) and a variant in LOC387715 (rs 10490924). Studies are inconsistent as to whether the associations differ by smoking history. We investigated this in the EUREYE study

Methods: : Participants underwent fundus imaging, were interviewed for risk factors including smoking and provided a blood sample. Images were graded at an independent centre (Rotterdam). All participants gave written, informed consent. Ethics approval was given in each study centre. Stored DNA was available on 560 early and 142 late AMD cases and 614 randomly selected controls frequency matched with cases by age, sex and centre. DNA was genotyped for rs 10490924 and rs4146894 using KASPar technology. We used multinomial logistic regression (Relative Risk Ratios-RRs) adjusted for age and sex and included a smoking x allele interaction term.

Results: : For rs10490924 the control T allele frequency was 35.5% of whom 3.6% were homozygous There were a significant (p=0.01) interaction with smoking and rs10490924 on AMD risk. For early AMD, the RRs (95% CI’s) for never smokers were GT:1.40 (1.12-1.77), p=0.004, TT: 2.15 (1.35-3.40), p<0.001. and for ever smokers GT:1.71 (1.39-2.09) p <0.0001 and TT:4.18 (2.11-8.29) p<0.0001. For late AMD the corresponding risks in never smokers was GT: 3.45 2.43-4.90), p=4.6 x10-12and TT: 7.45(3.48-15.93), p=2.2x10-7and ever smokers GT:3.11(1.59-6.10),p<0.001,TT:14.79(6.12-32.0),p=6.4x10-10.rs4146894 was weakly associated with AMD and not associated when rs 10490924 was added to the model.

Conclusions: : Smoking modified the association with rs10490924 and AMD.

Keywords: age-related macular degeneration • genetics • candidate gene analysis 

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