April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Relationship of Physical Activity to the Prevalence of Intermediate Age-Related Macular Degeneration (AMD) in the Carotenoids in Age-Related Eye Diseases Study (CAREDS), an Ancillary Study of the Women’s Health Initiative Observational Study (WHIOS)
Author Affiliations & Notes
  • R. Voland
    Ophthal and Visual Sciences,
    University of Wisconsin-Madison, Madison, Wisconsin
  • S. A. Sondel
    Ophthal and Visual Sciences,
    University of Wisconsin-Madison, Madison, Wisconsin
  • A. E. Millen
    Social and Preventive Medicine, University at Buffalo, Buffalo, New York
  • R. Chappell
    Biostatistics and Medical Informatics,
    University of Wisconsin-Madison, Madison, Wisconsin
  • B. A. Blodi
    Ophthal and Visual Sciences,
    University of Wisconsin-Madison, Madison, Wisconsin
  • G. E. Sarto
    Obstetrics & Gynecology,
    University of Wisconsin-Madison, Madison, Wisconsin
  • M. L. Klein
    Ophthalmology, Casey Eye Institute-OHSU, Portland, Oregon
  • K. M. Gehrs
    Ophthalmology, Univ of Iowa Hospitals & Clinics, Iowa City, Iowa
  • J. A. Mares
    Ophthal and Visual Sciences,
    University of Wisconsin-Madison, Madison, Wisconsin
  • Footnotes
    Commercial Relationships  R. Voland, None; S.A. Sondel, None; A.E. Millen, None; R. Chappell, None; B.A. Blodi, None; G.E. Sarto, None; M.L. Klein, None; K.M. Gehrs, None; J.A. Mares, None.
  • Footnotes
    Support  NIH EYO 16886 & 13018 Pes Pvnt Blndnss, & Retina Res Fnd
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4545. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R. Voland, S. A. Sondel, A. E. Millen, R. Chappell, B. A. Blodi, G. E. Sarto, M. L. Klein, K. M. Gehrs, J. A. Mares; Relationship of Physical Activity to the Prevalence of Intermediate Age-Related Macular Degeneration (AMD) in the Carotenoids in Age-Related Eye Diseases Study (CAREDS), an Ancillary Study of the Women’s Health Initiative Observational Study (WHIOS). Invest. Ophthalmol. Vis. Sci. 2010;51(13):4545.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : We investigated relationships between physical activity and the prevalence of intermediate AMD assessed an average of six years later.

Methods: : Post-menopausal women (ages 50-79 years) in this sample provided information about diet, lifestyle and risk factors at the time of entry into the WHI Observational Studies (1994-1997) in Iowa, Wisconsin and Oregon. Intermediate AMD was assessed from stereoscopic fundus photographs taken in CAREDS (2001-2004) (N=1,787.) For these analyses women under age 75 were selected (N=1,313) based on evidence for selective mortality bias in older women. At WHIOS baseline (1994-1998) women were asked about participation in total recreational physical activity (MET-hours/week) which includes walking, strenuous, moderate, and intensive activities.

Results: : Physical activity was strongly associated with a reduction in risk of AMD: The odds ratio [OR] (95% Confidence Interval [CI]) for AMD among women in the top quintile (> 25 MET-hrs/wk) compared with the bottom quintile (< 2.2 MET-hrs/week) of total recreational physical activity was 0.49 (0.28-0.84) P-trend = 0.005, after adjusting for age at eye photography, smoking packyears, history of diabetes, family history of AMD, iris pigment color, history of cardiovascular disease, hormone use status and score on 2005 Healthy Eating Index. This association may reflect, in part, lower body mass index (BMI) and better vitamin D status in woman who were physically active: In a sub sample of these women who had vitamin D values measured from serum (n=968) the OR (95% CI) for AMD was 0.52 (0.27-0.97) in high vs. low quintiles of MET-hrs/week; P-trend= 0.04 after adjusting for previously stated risk factors and was attenuated to 0.59 (0.30-1.12) P-trend = 0.10, after further adjustment for BMI and serum vitamin D.

Conclusions: : Greater physical activity was associated with reduced risk of intermediate AMD, a condition not severe enough to limit activity. This risk reduction may be partly mediated by lower BMI and better vitamin D status among physically active women.

Keywords: age-related macular degeneration • clinical (human) or epidemiologic studies: risk factor assessment • nutritional factors 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×