April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
EPHA2 Polymorphisms and Age-Related Cataract in India - Findings From the Indeye Genetics Study
A. Shanker; P. Sundaresan; P. Vashist; R. D. Ravindran; B. Talwar; G. Maraini; D. Nitsch; J. F. Hejtmancik; B. A. Nonyane; A. E. Fletcher
Author Affiliations & Notes
  • A. Shanker
    Aravind Medical Research Foundation, Madurai, India
  • P. Sundaresan
    Aravind Medical Research Foundation, Madurai, India
  • P. Vashist
    Dr.Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
  • R. D. Ravindran
    Aravind Eye Hospital, Pondicherry, India
  • B. Talwar
    Aravind Eye Hospital, Pondicherry, India
  • G. Maraini
    Dipartimento di Scienze Otorino-Odonto-Oftalmologiche e Cervico Facciali, Sezione di Oftalmologia, Universita` degli Studi di Parma, Parma, Italy
  • D. Nitsch
    Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
  • J. F. Hejtmancik
    Section on Ophthalmic Molecular Genetics, National Eye Institute, Bethesda USA, Maryland
  • B. A. Nonyane
    Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
  • A. E. Fletcher
    Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
  • Footnotes
    Commercial Relationships  A. Shanker, None; P. Sundaresan, None; P. Vashist, None; R.D. Ravindran, None; B. Talwar, None; G. Maraini, None; D. Nitsch, None; J.F. Hejtmancik, None; B.A. Nonyane, None; A.E. Fletcher, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 4547. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      EPHA2 Polymorphisms and Age-Related Cataract in India - Findings From the Indeye Genetics Study
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      A. Shanker, P. Sundaresan, P. Vashist, R. D. Ravindran, B. Talwar, G. Maraini, D. Nitsch, J. F. Hejtmancik, B. A. Nonyane, A. E. Fletcher; EPHA2 Polymorphisms and Age-Related Cataract in India - Findings From the Indeye Genetics Study. Invest. Ophthalmol. Vis. Sci. 2010;51(13):4547.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Age-related cataract is a major cause of blindness worldwide. Previous studies have shown that the gene EPHA2 is associated with age-related cataract in those of European descent. The aim of the present study was to confirm previous associations of single nucleotide polymorphisms (SNPs) in a study of age-related cataract in India.

Methods: : 7068 participants aged 40 and above from the two centres (North and South India) of the INDEYE study gave consent to blood collection and genotyping. Digitised lens images of each eye were graded by the Lens Opacification Classification System (LOCS III). The prevalence of any type of cataract (nuclear >=4 or cortical >=3, Posterior SubCapsular PSC>=2, or dense or operated in either eye) increased with age. Genotyping of rs3754334 and rs7543472 was carried out with RT-PCR. Logistic regression was used to determine the association between any type of cataract and SNPs, adjusted for age, sex, study centre and clustering in villages. Associations were examined also with specific types of cataract.

Results: : Genotype frequencies for rs3754334 were 43% (CC), 45% (CT) and 12% (TT) in controls and for rs7543472 63% (CC), 34% (CT) and 4% (TT) with no violation of Hardy-Weinberg Equilibrium (p=0.75 and 0.54, respectively). There was no evidence for an association of rs3754334 TT with cataract (p=0.57), nor was there evidence for an association with cortical cataract (p=0.69), nor PSC (p=0.94), nor nuclear cataract (p=0.92).There was a borderline association between rs7543472 TT and any form of cataract when compared to rs7543472 CC with an odds ratio (OR) of 1.31 with 95% confidence interval (0.97, 1.77); p=0.074. This association reflected mainly the association of rs7543472 TT with cortical cataract with OR 2.06 (1.14, 3.70); p=0.015 and PSC with OR 1.73 (1.20, 2.51); p=0.004. There was weaker association of rs7543472 TT with nuclear cataract with OR 1.37 (1.01, 1.88); p=0.045.

Conclusions: : In the Indian population there is evidence for association of rs7543472 with age-related cataract, in particular cortical and posterior sub-capsular forms.

Keywords: cataract • genetics • clinical (human) or epidemiologic studies: prevalence/incidence 
© 2010, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept